Selective ablation of P53 in pancreatic beta cells fails to ameliorate glucose metabolism in genetic, dietary and pharmacological models of diabetes mellitus

Beta cell dysfunction and death are critical steps in the development of both type 1 and type 2 diabetes (T1D and T2D), but the underlying mechanisms are incompletely understood. Activation of the essential tumor suppressor and transcription factor P53 (also known as TP53 and Trp53 in mice) was link...

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Bibliographic Details
Published in:	Molecular metabolism (Germany) Vol. 67; p. 101650
Main Authors:	Uhlemeyer, Celina, Müller, Nadine, Rieck, Michael, Kuboth, Jennifer, Schlegel, Caroline, Grieß, Kerstin, Dorweiler, Tim Florian, Heiduschka, Sonja, Eckel, Jürgen, Roden, Michael, Lammert, Eckhard, Stoffel, Markus, Belgardt, Bengt-Frederik
Format:	Journal Article
Language:	English
Published:	Germany Elsevier GmbH 01-01-2023 Elsevier
Subjects:	Animals Apoptosis Brief Communication Diabetes Mellitus, Type 2 - metabolism Glucose - metabolism Humans Insulin - metabolism Insulin-Secreting Cells - metabolism Mice Pancreatic beta cell Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism Type 1 diabetes Type 2 diabetes Type 2 diabetes Type 1 diabetes Pancreatic beta cell Apoptosis
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