Effects of DNA methyltransferase inhibitors (DNMTIs) on MDS-derived cell lines

DNA methyltransferase inhibitors (DNMTIs), including decitabine (DAC) and azacitidine (AZA), have recently been highlighted for the treatment of high-risk myelodysplastic syndrome (MDS); however, their action mechanisms have not been clearly defined. Therefore, we investigated the effects of DNMTIs...

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Bibliographic Details
Published in:	Experimental hematology Vol. 41; no. 2; pp. 189 - 197
Main Authors:	Tsujioka, Takayuki, Yokoi, Akira, Uesugi, Mai, Kishimoto, Mitsuyo, Tochigi, Aki, Suemori, Sinichiro, Tohyama, Yumi, Tohyama, Kaoru
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier Inc 01-02-2013
Subjects:	Advanced Basic Science Azacitidine - analogs & derivatives Azacitidine - pharmacology Cell Cycle - drug effects Cell Division - drug effects Cell Line - drug effects DNA (Cytosine-5-)-Methyltransferase 1 DNA (Cytosine-5-)-Methyltransferases - antagonists & inhibitors DNA Damage DNA Methylation - drug effects Dose-Response Relationship, Drug Enzyme Inhibitors - pharmacology Gene Expression Profiling Hematology, Oncology and Palliative Medicine HL-60 Cells - drug effects Humans In Vitro Techniques Inhibitory Concentration 50 Myelodysplastic Syndromes - pathology
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