Treatment of donor graft failure with nonmyeloablative conditioning of fludarabine, antithymocyte globulin and a second allogeneic hematopoietic transplantation

Graft failure is a life-threatening complication of allogeneic stem cell transplantation (SCT). We assessed the feasibility of performing a second SCT after such failure when fludarabine and antithymocyte globulin (ATG) are used for non-myeloablative conditioning and tacrolimus for graft-versus-host...

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Bibliographic Details
Published in:	Bone marrow transplantation (Basingstoke) Vol. 40; no. 5; pp. 431 - 435
Main Authors:	JABBOUR, E, RONDON, G, ANDERLINI, P, GIRALT, S. A, COURIEL, D. R, CHAMPLIN, R. E, KHOURI, I. F
Format:	Journal Article
Language:	English
Published:	Basingstoke Nature Publishing Group 01-09-2007
Subjects:	Adult Aged Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy Antilymphocyte serum Antilymphocyte Serum - administration & dosage Antithymocyte globulin Biological and medical sciences Bone marrow, stem cells transplantation. Graft versus host reaction Conditioning Cord blood Disease prevention Dosage and administration Drug therapy Failure Feasibility Studies Female Fludarabine Globulins Graft Rejection Graft Survival Graft versus host disease Graft versus host reaction Graft vs Host Disease - drug therapy Graft vs Host Disease - prevention & control Grafting Grafts Hematopoiesis Hematopoietic Stem Cell Transplantation - adverse effects Hematopoietic Stem Cell Transplantation - methods Hematopoietic stem cells Humans Male Medical sciences Middle Aged Patients Physiological aspects Pilot Projects Prophylaxis Risk factors Salvage Therapy - methods Stem cell transplantation Stem cells Tacrolimus Tacrolimus - therapeutic use Thymocytes Transfusions. Complications. Transfusion reactions. Cell and gene therapy Transplantation Transplantation Conditioning - methods Transplantation, Autologous Transplants & implants Vidarabine - administration & dosage Vidarabine - analogs & derivatives United States Antineoplastic agent Purine nucleotide Hematology Homograft Non myeloablative treatment second transplant Graft failure Second transplantation Fludarabine Treatment Antimetabolic Immunotherapy Graft Myelosuppression Fluorine Organic compounds Antithymocyte globulin non-ablative conditioning
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