Common Genetic Variation in Humans Impacts In Vitro Susceptibility to SARS-CoV-2 Infection

The host response to SARS-CoV-2, the etiologic agent of the COVID-19 pandemic, demonstrates significant interindividual variability. In addition to showing more disease in males, the elderly, and individuals with underlying comorbidities, SARS-CoV-2 can seemingly afflict healthy individuals with pro...

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Bibliographic Details
Published in:	Stem cell reports Vol. 16; no. 3; pp. 505 - 518
Main Authors:	Dobrindt, Kristina, Hoagland, Daisy A., Seah, Carina, Kassim, Bibi, O'Shea, Callan P., Murphy, Aleta, Iskhakova, Marina, Fernando, Michael B., Powell, Samuel K., Deans, P.J. Michael, Javidfar, Ben, Peter, Cyril, Møller, Rasmus, Uhl, Skyler A., Garcia, Meilin Fernandez, Kimura, Masaki, Iwasawa, Kentaro, Crary, John F., Kotton, Darrell N., Takebe, Takanori, Huckins, Laura M., tenOever, Benjamin R., Akbarian, Schahram, Brennand, Kristen J.
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 09-03-2021 Elsevier
Subjects:	3' Untranslated Regions - genetics Adolescent Adult Animals brain Cell Line Chlorocebus aethiops Clustered Regularly Interspaced Short Palindromic Repeats - genetics COVID-19 - genetics COVID-19 - virology Female Furin - genetics FURIN rs4702 Genetic Predisposition to Disease - genetics host genetics Host-Pathogen Interactions - genetics human induced pluripotent stem cell Humans Induced Pluripotent Stem Cells - virology Male neurons Neurons - virology Peptide Hydrolases - genetics Polymorphism, Single Nucleotide - genetics SARS-CoV-2 SARS-CoV-2 - pathogenicity Vero Cells human induced pluripotent stem cell host genetics SARS-CoV-2 FURIN rs4702 brain neurons
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