Induction of cystine and glutamate transport activity in human fibroblasts by diethyl maleate and other electrophilic agents

The transport activity for cystine and glutamate in cultured human diploid fibroblasts is enhanced in response to diethyl maleate treatment. The enhancement is time- and dose-related, with a lag of about 3 h, and maximum enhancement (approximately 3-fold increase in the rate of uptake) is attained a...

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Bibliographic Details
Published in:	The Journal of biological chemistry Vol. 259; no. 4; pp. 2435 - 2440
Main Author:	Bannai, S
Format:	Journal Article
Language:	English
Published:	Bethesda, MD Elsevier Inc 25-02-1984 American Society for Biochemistry and Molecular Biology
Subjects:	Biological and medical sciences Biological Transport - drug effects Cell Line Cell physiology Cystine - metabolism Female Fibroblasts - drug effects Fibroblasts - metabolism Fundamental and applied biological sciences. Psychology Glutamates - metabolism Glutamic Acid Humans Kinetics Lung - embryology Maleates - pharmacology Membrane and intracellular transports Molecular and cellular biology Pregnancy Structure-Activity Relationship Human Cell culture Glutamic acid Membrane transport Aminoacid Lung Activation Fibroblast Cystine
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