A Persistence Detector for Metabolic Network Rewiring in an Animal

Biological systems must possess mechanisms that prevent inappropriate responses to spurious environmental inputs. Caenorhabditis elegans has two breakdown pathways for the short-chain fatty acid propionate: a canonical, vitamin B12-dependent pathway and a propionate shunt that is used when vitamin B...

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Bibliographic Details
Published in:	Cell reports (Cambridge) Vol. 26; no. 2; pp. 460 - 468.e4
Main Authors:	Bulcha, Jote T., Giese, Gabrielle E., Ali, Md. Zulfikar, Lee, Yong-Uk, Walker, Melissa D., Holdorf, Amy D., Yilmaz, L. Safak, Brewster, Robert C., Walhout, Albertha J.M.
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 08-01-2019 Elsevier
Subjects:	AND-logic gate Animals C. elegans Caenorhabditis elegans feed-forward loop gene regulatory network Homeostasis Metabolic Networks and Pathways metabolism persistence detector propionate Propionates - metabolism Receptors, Cytoplasmic and Nuclear - genetics Receptors, Cytoplasmic and Nuclear - metabolism transcription factor Transcriptome Vitamin B 12 - metabolism vitamin B12 feed-forward loop transcription factor AND-logic gate C. elegans vitamin B12 metabolism persistence detector gene regulatory network propionate
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