Liver Metabolomics and Inflammatory Profiles in Mouse Model of Fentanyl Overdose Treated with Beta-Lactams

Fentanyl is a highly potent opioid analgesic that is approved medically to treat acute and chronic pain. There is a high potential for overdose-induced organ toxicities, including liver toxicity, and this might be due to the increase of recreational use of opioids. Several preclinical studies have d...

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Bibliographic Details
Published in:	Metabolites Vol. 13; no. 8; p. 965
Main Authors:	Alasmari, Fawaz, Alasmari, Mohammed S, Assiri, Mohammed A, Alswayyed, Mohammed, Rizwan Ahamad, Syed, Alhumaydhi, Abdulrahman I, Arif, Bandar I, Aljumayi, Sahar R, AlAsmari, Abdullah F, Ali, Nemat, Childers, Wayne E, Abou-Gharbia, Magid, Sari, Youssef
Format:	Journal Article
Language:	English
Published:	Basel MDPI AG 01-08-2023 MDPI
Subjects:	Alzheimer's disease Amino acids Amphetamines Analgesics Antibiotics Beta lactam antibiotics beta-lactams Biomarkers Brain Carbohydrates Ceftriaxone Chromatography Chronic pain Dosage and administration Drug abuse Drug dosages Drug overdose Drugs Ethanol Fatty acids Fentanyl Gas chromatography Gluconeogenesis Glutamic acid transporter Health aspects Heroin Inflammation Interleukin 6 Ions Lactose Liver Mass spectrometry Mass spectroscopy MC-100093 Metabolism Metabolites metabolomic Metabolomics Morphine Narcotics Opioids Overdose Pharmaceutical industry Pharmacology, Experimental Physiological aspects Scientific imaging Statistical analysis Toxicity β-Lactam antibiotics Saudi Arabia United States > US
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