Antiurolithiatic effect of lithocare against ethylene glycol-induced urolithiasis in Wistar rats

• Published in: Indian journal of pharmacology Vol. 48; no. 1; pp. 78 - 82
• Main Authors: Lulat, Sumaiya I, Yadav, Yogesh Chand, Balaraman, R, Maheshwari, Rajesh
• Format: Journal Article
• Language: English
• Published: India Medknow Publications and Media Pvt. Ltd 01-01-2016; Medknow Publications & Media Pvt. Ltd; Medknow Publications & Media Pvt Ltd
• Subjects: Administration, Oral; Animals; Antifreeze solutions; Dose-Response Relationship, Drug; Ethylene Glycol - toxicity; Ethylene glycols; Health aspects; Herbal Medicine; Kidneys; Male; Medicinal plants; Physiological aspects; Rats; Rats, Wistar; Rodents; Short Communication; Studies; Urinary stones; Urolithiasis - chemically induced; Urolithiasis - prevention & control; lithocare; urolithiasis; Ethylene glycol; Wistar rats; polyherbal formulation
• ISSN: 0253-7613; 1998-3751
• DOI: 10.4103/0253-7613.174564

This study is aimed to investigate the protective effect of Lithocare (LC) (a polyherbal formulation) against ethylene glycol (EG) induced urolithiasis in Wistar rats.
The protective effect of LC (400 and 800 mg/kg) was evaluated using EG-induced urolithiasis in rats.
Administration of EG in drinking water resulted in hyperoxaluria, hypocalcemia as well as an increased renal excretion of phosphate. Supplementation with LC significantly reduced the urinary calcium, oxalate, and phosphate excretion dose-dependently. There was a significant reduction in the levels of calcium, oxalate as well as a number of calcium oxalate crystals deposits in the kidney tissue of rats administered with LC in EG-treated rats. There was a significant reduction in creatinine, urea, uric acid, and blood urea nitrogen when LC was administered in EG-treated rats.
From this study, it was concluded that the supplementation of LC protected EG-induced urolithiasis as it reduced the growth of urinary stones. The mechanism underlying this effect might be due to its antioxidant, diuretic, and reduction in stone-forming constituents.