Effect of omeprazole on the plasma concentrations of indinavir when administered alone and in combination with ritonavir

• Published in: American journal of health-system pharmacy Vol. 65; no. 5; pp. 422 - 428
• Main Authors: Tappouni, Hiba L, Rublein, John C, Donovan, Brian J, Hollowell, Stephanie B, Tien, Hsiao-Chuan, Min, Sherene S, Theodore, Dickens, Rezk, Naser L, Smith, Philip C, Tallman, Melanie N, Raasch, Ralph H, Kashuba, Angela D M
• Format: Journal Article
• Language: English
• Published: England American Society of Health-System Pharmacists 01-03-2008; Oxford University Press
• Subjects: Adolescent; Adult; Anti-Ulcer Agents - administration & dosage; Anti-Ulcer Agents - pharmacology; Area Under Curve; Chromatography, High Pressure Liquid; Complications and side effects; Dosage and administration; Dose-Response Relationship, Drug; Drug Interactions; Drug Therapy, Combination; Female; HIV Protease Inhibitors - pharmacokinetics; HIV Protease Inhibitors - pharmacology; Human immunodeficiency virus; Humans; Indinavir; Indinavir - pharmacokinetics; Male; Middle Aged; Omeprazole; Omeprazole - administration & dosage; Omeprazole - pharmacology; Ritonavir; Ritonavir - pharmacology; United States
• ISSN: 1079-2082; 1535-2900
• DOI: 10.2146/ajhp070226

The effects of omeprazole on indinavir when administered alone or in combination with ritonavir were evaluated.
Fourteen men and women age 18-55 years not infected with human immunodeficiency virus who met study qualifications were randomized to receive placebo, 20 mg of omeprazole, or 40 mg of omeprazole daily. After seven days, the single-dose pharmacokinetic profile of an 800-mg dose of indinavir alone or in combination with 200 mg of ritonavir was evaluated. Study participants received each of four study regimens in one of four randomly assigned orders. Blood samples were collected, and plasma indinavir and ritonavir concentrations were analyzed using high-performance liquid chromatography.
The coadministration of 20 or 40 mg of omeprazole with indinavir significantly reduced the mean indinavir area under the concentration-versus-time curve (AUC) from 30.0 mg x hr/L (95% confidence interval [CI], 21.9-41.1 mg x hr/L) to 19.7 mg x hr/L (95% CI, 14.6-26.8 mg x hr/L) or 16.0 mg x hr/L (95% CI, 11.8-21.7 mg x hr/L), respectively (p < 0.002). The addition of 200 mg of ritonavir to 800 mg of indinavir in combination with 40 mg of omeprazole significantly increased the mean indinavir AUC from 30.0 mg x hr/L (95% CI, 21.9-41.1 mg x hr/L) to 46.6 mg x hr/L (95% CI, 34.0-63.8 mg x hr/L), but it did not significantly affect mean omeprazole concentrations (p < or = 0.02).
The AUC of indinavir was substantially decreased in healthy volunteers who received omeprazole 20 or 40 mg daily for seven days before the administration of a single 800-mg dose of indinavir. Concomitant administration of ritonavir 200 mg with indinavir in participants receiving omeprazole led to a significant increase in the AUC of indinavir.