Pleomorphic (spindle and squamous cell) carcinoma arising in a peripheral mixed squamous and glandular papilloma in a 70-year-old man

Solitary papillomas of the bronchial tree are rare, particularly in the distal airways. When encountered, solitary papillomas are not frequently found to undergo malignant transformation. When this does happen, it is usually a squamous cell carcinoma arising in a human papillomavirus-associated squa...

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Bibliographic Details
Published in:	Archives of pathology & laboratory medicine (1976) Vol. 135; no. 10; pp. 1353 - 1356
Main Authors:	Lagana, Stephen M, Hanna, Robert F, Borczuk, Alain C
Format:	Journal Article
Language:	English
Published:	United States College of American Pathologists 01-10-2011
Subjects:	Aged Bronchial Neoplasms - pathology Carcinoma, Squamous Cell - pathology Development and progression Diagnosis, Differential Humans Male Neoplasms, Complex and Mixed - pathology Papilloma - pathology Papillomaviridae - isolation & purification Papillomavirus infections Squamous cell carcinoma
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Summary:	Solitary papillomas of the bronchial tree are rare, particularly in the distal airways. When encountered, solitary papillomas are not frequently found to undergo malignant transformation. When this does happen, it is usually a squamous cell carcinoma arising in a human papillomavirus-associated squamous papilloma (usually in a central airway). Here we report a unique case of pleomorphic (spindle and squamous cell) carcinoma arising in a mixed glandular and squamous papilloma without human papillomavirus association.
Bibliography:	ObjectType-Case Study-2 SourceType-Scholarly Journals-1 ObjectType-Feature-4 content type line 23 ObjectType-Report-1 ObjectType-Article-3
ISSN:	0003-9985 1543-2165 1543-2165
DOI:	10.5858/arpa.2010-0420-cr