BDK inhibition acts as a catabolic switch to mimic fasting and improve metabolism in mice

Branched chain amino acid (BCAA) catabolic defects are implicated to be causal determinates of multiple diseases. This work aimed to better understand how enhancing BCAA catabolism affected metabolic homeostasis as well as the mechanisms underlying these improvements. The rate limiting step of BCAA...

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Bibliographic Details
Published in:	Molecular metabolism (Germany) Vol. 66; p. 101611
Main Authors:	Bollinger, Eliza, Peloquin, Matthew, Libera, Jenna, Albuquerque, Bina, Pashos, Evanthia, Shipstone, Arun, Hadjipanayis, Angela, Sun, Zhongyuan, Xing, Gang, Clasquin, Michelle, Stansfield, John C., Tierney, Brendan, Gernhardt, Steven, Siddall, C. Parker, Greizer, Timothy, Geoly, Frank J., Vargas, Sarah R., Gao, Lily C., Williams, George, Marshall, Mackenzie, Rosado, Amy, Steppan, Claire, Filipski, Kevin J., Zhang, Bei B., Miller, Russell A., Roth Flach, Rachel J.
Format:	Journal Article
Language:	English
Published:	Germany Elsevier GmbH 01-12-2022 Elsevier
Subjects:	3-Methyl-2-Oxobutanoate Dehydrogenase (Lipoamide) - metabolism Amino Acids, Branched-Chain - metabolism Animals BCAA Diabetes Fasting Fatty Liver Metabolic syndrome Metabolism Mice Mice, Knockout NAFLD Original PPAR alpha RNA, Small Interfering NAFLD Diabetes Metabolism Metabolic syndrome BCAA
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