SLFN11 Blocks Stressed Replication Forks Independently of ATR

SLFN11 sensitizes cancer cells to a broad range of DNA-targeted therapies. Here we show that, in response to replication stress induced by camptothecin, SLFN11 tightly binds chromatin at stressed replication foci via RPA1 together with the replication helicase subunit MCM3. Unlike ATR, SLFN11 neithe...

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Bibliographic Details
Published in:Molecular cell Vol. 69; no. 3; pp. 371 - 384.e6
Main Authors: Murai, Junko, Tang, Sai-Wen, Leo, Elisabetta, Baechler, Simone A., Redon, Christophe E., Zhang, Hongliang, Al Abo, Muthana, Rajapakse, Vinodh N., Nakamura, Eijiro, Jenkins, Lisa M. Miller, Aladjem, Mirit I., Pommier, Yves
Format: Journal Article
Language:English
Published: United States Elsevier Inc 01-02-2018
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