Fibronectin concentrations in catheter sepsis

• Published in: Clinical microbiology and infection Vol. 6; no. 3; pp. 121 - 124
• Main Authors: Nemet, B., Žagar, Ž.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Elsevier Ltd 01-03-2000; Blackwell Science Ltd; Blackwell; Elsevier Limited
• Subjects: Aged; Aged, 80 and over; Bacteremia - blood; Bacteremia - etiology; Bacterial Adhesion; Biological and medical sciences; catheter sepsis; Catheters, Indwelling - adverse effects; Catheters, Indwelling - microbiology; coagulase-negative staphylococci; Fibronectin; Fibronectins - blood; Humans; Immunodiffusion; Investigative techniques, diagnostic techniques (general aspects); Male; Medical sciences; Middle Aged; Miscellaneous. Technology; Pathology. Cytology. Biochemistry. Spectrometry. Miscellaneous investigative techniques; Sepsis - blood; Sepsis - etiology; Staphylococcal Infections - blood; Staphylococcal Infections - etiology; Staphylococcus - isolation & purification; Staphylococcus - pathogenicity; Time Factors; catheter sepsis; Fibronectin; coagulase-negative staphylococci; Human; Glycoprotein; Negative capacity; Coagulation; Instrumentation therapy; Catheter; Concentration; Staphylococcus; Result; Infection; Sepsis syndrome; Bacteriosis; Bacteria; Micrococcales; Micrococcaceae; Mechanism of action; Comparative study
• ISSN: 1198-743X; 1469-0691
• DOI: 10.1046/j.1469-0691.2000.00029.x

To investigate the role of fibronectin in the pathogenesis of biomaterial-related infections and the influence of catheter sepsis on the concentration of plasma fibronectin during various stages of bacteremia.
Plasma fibronectin concentrations were determined by the simple radial immunodiffusion method. Four groups of subjects were used: one group comprised patients with catheter sepsis, the second patients with local inflammation of the catheter insertion site caused by slime-positive, coagulase-negative staphylococci, the third patients with slime-negative, coagulase-negative staphylococci isolated from the catheter, and the fourth demonstrably healthy persons.
In patients with catheter sepsis, fibronectin concentrations were found after the disappearance of catheter sepsis and 3-5 days after the removal of the catheter. A statistically significant decrease in fibronectin concentration was detected in the plasma of patients with catheter sepsis compared with other groups of patients and control subjects.
The above results indicate a pathogenic role for fibronectin in biomaterial-related infections.