Monitoring the Remodeling of Biohybrid Tissue‐Engineered Vascular Grafts by Multimodal Molecular Imaging

Tissue‐engineered vascular grafts (TEVGs) with the ability to grow and remodel open new perspectives for cardiovascular surgery. Equipping TEVGs with synthetic polymers and biological components provides a good compromise between high structural stability and biological adaptability. However, imagin...

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Published in:	Advanced science Vol. 9; no. 10; pp. e2105783 - n/a
Main Authors:	Rama, Elena, Mohapatra, Saurav Ranjan, Melcher, Christoph, Nolte, Teresa, Dadfar, Seyed Mohammadali, Brueck, Ramona, Pathak, Vertika, Rix, Anne, Gries, Thomas, Schulz, Volkmar, Lammers, Twan, Apel, Christian, Jockenhoevel, Stefan, Kiessling, Fabian
Format:	Journal Article
Language:	English
Published:	Germany John Wiley & Sons, Inc 01-04-2022 John Wiley and Sons Inc Wiley
Subjects:	Biocompatibility Biodegradation Blood Vessel Prosthesis Collagen Extracellular Matrix Magnetic resonance imaging Molecular Imaging Nanoparticles poly(lactic‐co‐glycolic acid) Prostheses superparamagnetic iron‐oxide nanoparticles Synthetic products Tissue Engineering - methods tissue‐engineering Transplants & implants Ultrasonic imaging αvβ3 integrins United States > US poly(lactic-co-glycolic acid) superparamagnetic iron-oxide nanoparticles tissue-engineering molecular imaging αvβ3 integrins
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Abstract	Tissue‐engineered vascular grafts (TEVGs) with the ability to grow and remodel open new perspectives for cardiovascular surgery. Equipping TEVGs with synthetic polymers and biological components provides a good compromise between high structural stability and biological adaptability. However, imaging approaches to control grafts’ structural integrity, physiological function, and remodeling during the entire transition between late in vitro maturation and early in vivo engraftment are mandatory for clinical implementation. Thus, a comprehensive molecular imaging concept using magnetic resonance imaging (MRI) and ultrasound (US) to monitor textile scaffold resorption, extracellular matrix (ECM) remodeling, and endothelial integrity in TEVGs is presented here. Superparamagnetic iron‐oxide nanoparticles (SPION) incorporated in biodegradable poly(lactic‐co‐glycolic acid) (PLGA) fibers of the TEVGs allow to quantitatively monitor scaffold resorption via MRI both in vitro and in vivo. Additionally, ECM formation can be depicted by molecular MRI using elastin‐ and collagen‐targeted probes. Finally, molecular US of αvβ3 integrins confirms the absence of endothelial dysfunction; the latter is provocable by TNF‐α. In conclusion, the successful employment of noninvasive molecular imaging to longitudinally evaluate TEVGs remodeling is demonstrated. This approach may foster its translation from in vitro quality control assessment to in vivo applications to ensure proper prostheses engraftment. Noninvasive imaging modalities are fundamental to control the remodeling and function of biohybrid tissue‐engineered vascular grafts, which is particularly true for the critical transition time between late in vitro maturation and early in vivo engraftment. Here, a noninvasive multimodal, molecular imaging concept is presented to longitudinally monitor textile scaffold resorption, extracellular matrix remodeling, and endothelial inflammation.
AbstractList	Abstract Tissue‐engineered vascular grafts (TEVGs) with the ability to grow and remodel open new perspectives for cardiovascular surgery. Equipping TEVGs with synthetic polymers and biological components provides a good compromise between high structural stability and biological adaptability. However, imaging approaches to control grafts’ structural integrity, physiological function, and remodeling during the entire transition between late in vitro maturation and early in vivo engraftment are mandatory for clinical implementation. Thus, a comprehensive molecular imaging concept using magnetic resonance imaging (MRI) and ultrasound (US) to monitor textile scaffold resorption, extracellular matrix (ECM) remodeling, and endothelial integrity in TEVGs is presented here. Superparamagnetic iron‐oxide nanoparticles (SPION) incorporated in biodegradable poly(lactic‐co‐glycolic acid) (PLGA) fibers of the TEVGs allow to quantitatively monitor scaffold resorption via MRI both in vitro and in vivo. Additionally, ECM formation can be depicted by molecular MRI using elastin‐ and collagen‐targeted probes. Finally, molecular US of αvβ3 integrins confirms the absence of endothelial dysfunction; the latter is provocable by TNF‐α. In conclusion, the successful employment of noninvasive molecular imaging to longitudinally evaluate TEVGs remodeling is demonstrated. This approach may foster its translation from in vitro quality control assessment to in vivo applications to ensure proper prostheses engraftment. Tissue‐engineered vascular grafts (TEVGs) with the ability to grow and remodel open new perspectives for cardiovascular surgery. Equipping TEVGs with synthetic polymers and biological components provides a good compromise between high structural stability and biological adaptability. However, imaging approaches to control grafts’ structural integrity, physiological function, and remodeling during the entire transition between late in vitro maturation and early in vivo engraftment are mandatory for clinical implementation. Thus, a comprehensive molecular imaging concept using magnetic resonance imaging (MRI) and ultrasound (US) to monitor textile scaffold resorption, extracellular matrix (ECM) remodeling, and endothelial integrity in TEVGs is presented here. Superparamagnetic iron‐oxide nanoparticles (SPION) incorporated in biodegradable poly(lactic‐co‐glycolic acid) (PLGA) fibers of the TEVGs allow to quantitatively monitor scaffold resorption via MRI both in vitro and in vivo. Additionally, ECM formation can be depicted by molecular MRI using elastin‐ and collagen‐targeted probes. Finally, molecular US of αvβ3 integrins confirms the absence of endothelial dysfunction; the latter is provocable by TNF‐α. In conclusion, the successful employment of noninvasive molecular imaging to longitudinally evaluate TEVGs remodeling is demonstrated. This approach may foster its translation from in vitro quality control assessment to in vivo applications to ensure proper prostheses engraftment. Tissue-engineered vascular grafts (TEVGs) with the ability to grow and remodel open new perspectives for cardiovascular surgery. Equipping TEVGs with synthetic polymers and biological components provides a good compromise between high structural stability and biological adaptability. However, imaging approaches to control grafts' structural integrity, physiological function, and remodeling during the entire transition between late in vitro maturation and early in vivo engraftment are mandatory for clinical implementation. Thus, a comprehensive molecular imaging concept using magnetic resonance imaging (MRI) and ultrasound (US) to monitor textile scaffold resorption, extracellular matrix (ECM) remodeling, and endothelial integrity in TEVGs is presented here. Superparamagnetic iron-oxide nanoparticles (SPION) incorporated in biodegradable poly(lactic-co-glycolic acid) (PLGA) fibers of the TEVGs allow to quantitatively monitor scaffold resorption via MRI both in vitro and in vivo. Additionally, ECM formation can be depicted by molecular MRI using elastin- and collagen-targeted probes. Finally, molecular US of α β integrins confirms the absence of endothelial dysfunction; the latter is provocable by TNF-α. In conclusion, the successful employment of noninvasive molecular imaging to longitudinally evaluate TEVGs remodeling is demonstrated. This approach may foster its translation from in vitro quality control assessment to in vivo applications to ensure proper prostheses engraftment. Tissue‐engineered vascular grafts (TEVGs) with the ability to grow and remodel open new perspectives for cardiovascular surgery. Equipping TEVGs with synthetic polymers and biological components provides a good compromise between high structural stability and biological adaptability. However, imaging approaches to control grafts’ structural integrity, physiological function, and remodeling during the entire transition between late in vitro maturation and early in vivo engraftment are mandatory for clinical implementation. Thus, a comprehensive molecular imaging concept using magnetic resonance imaging (MRI) and ultrasound (US) to monitor textile scaffold resorption, extracellular matrix (ECM) remodeling, and endothelial integrity in TEVGs is presented here. Superparamagnetic iron‐oxide nanoparticles (SPION) incorporated in biodegradable poly(lactic‐ co ‐glycolic acid) (PLGA) fibers of the TEVGs allow to quantitatively monitor scaffold resorption via MRI both in vitro and in vivo. Additionally, ECM formation can be depicted by molecular MRI using elastin‐ and collagen‐targeted probes. Finally, molecular US of α v β 3 integrins confirms the absence of endothelial dysfunction; the latter is provocable by TNF‐ α . In conclusion, the successful employment of noninvasive molecular imaging to longitudinally evaluate TEVGs remodeling is demonstrated. This approach may foster its translation from in vitro quality control assessment to in vivo applications to ensure proper prostheses engraftment. Noninvasive imaging modalities are fundamental to control the remodeling and function of biohybrid tissue‐engineered vascular grafts, which is particularly true for the critical transition time between late in vitro maturation and early in vivo engraftment. Here, a noninvasive multimodal, molecular imaging concept is presented to longitudinally monitor textile scaffold resorption, extracellular matrix remodeling, and endothelial inflammation. Tissue-engineered vascular grafts (TEVGs) with the ability to grow and remodel open new perspectives for cardiovascular surgery. Equipping TEVGs with synthetic polymers and biological components provides a good compromise between high structural stability and biological adaptability. However, imaging approaches to control grafts' structural integrity, physiological function, and remodeling during the entire transition between late in vitro maturation and early in vivo engraftment are mandatory for clinical implementation. Thus, a comprehensive molecular imaging concept using magnetic resonance imaging (MRI) and ultrasound (US) to monitor textile scaffold resorption, extracellular matrix (ECM) remodeling, and endothelial integrity in TEVGs is presented here. Superparamagnetic iron-oxide nanoparticles (SPION) incorporated in biodegradable poly(lactic-co-glycolic acid) (PLGA) fibers of the TEVGs allow to quantitatively monitor scaffold resorption via MRI both in vitro and in vivo. Additionally, ECM formation can be depicted by molecular MRI using elastin- and collagen-targeted probes. Finally, molecular US of αv β3 integrins confirms the absence of endothelial dysfunction; the latter is provocable by TNF-α. In conclusion, the successful employment of noninvasive molecular imaging to longitudinally evaluate TEVGs remodeling is demonstrated. This approach may foster its translation from in vitro quality control assessment to in vivo applications to ensure proper prostheses engraftment.Tissue-engineered vascular grafts (TEVGs) with the ability to grow and remodel open new perspectives for cardiovascular surgery. Equipping TEVGs with synthetic polymers and biological components provides a good compromise between high structural stability and biological adaptability. However, imaging approaches to control grafts' structural integrity, physiological function, and remodeling during the entire transition between late in vitro maturation and early in vivo engraftment are mandatory for clinical implementation. Thus, a comprehensive molecular imaging concept using magnetic resonance imaging (MRI) and ultrasound (US) to monitor textile scaffold resorption, extracellular matrix (ECM) remodeling, and endothelial integrity in TEVGs is presented here. Superparamagnetic iron-oxide nanoparticles (SPION) incorporated in biodegradable poly(lactic-co-glycolic acid) (PLGA) fibers of the TEVGs allow to quantitatively monitor scaffold resorption via MRI both in vitro and in vivo. Additionally, ECM formation can be depicted by molecular MRI using elastin- and collagen-targeted probes. Finally, molecular US of αv β3 integrins confirms the absence of endothelial dysfunction; the latter is provocable by TNF-α. In conclusion, the successful employment of noninvasive molecular imaging to longitudinally evaluate TEVGs remodeling is demonstrated. This approach may foster its translation from in vitro quality control assessment to in vivo applications to ensure proper prostheses engraftment. Tissue‐engineered vascular grafts (TEVGs) with the ability to grow and remodel open new perspectives for cardiovascular surgery. Equipping TEVGs with synthetic polymers and biological components provides a good compromise between high structural stability and biological adaptability. However, imaging approaches to control grafts’ structural integrity, physiological function, and remodeling during the entire transition between late in vitro maturation and early in vivo engraftment are mandatory for clinical implementation. Thus, a comprehensive molecular imaging concept using magnetic resonance imaging (MRI) and ultrasound (US) to monitor textile scaffold resorption, extracellular matrix (ECM) remodeling, and endothelial integrity in TEVGs is presented here. Superparamagnetic iron‐oxide nanoparticles (SPION) incorporated in biodegradable poly(lactic‐co‐glycolic acid) (PLGA) fibers of the TEVGs allow to quantitatively monitor scaffold resorption via MRI both in vitro and in vivo. Additionally, ECM formation can be depicted by molecular MRI using elastin‐ and collagen‐targeted probes. Finally, molecular US of αvβ3 integrins confirms the absence of endothelial dysfunction; the latter is provocable by TNF‐α. In conclusion, the successful employment of noninvasive molecular imaging to longitudinally evaluate TEVGs remodeling is demonstrated. This approach may foster its translation from in vitro quality control assessment to in vivo applications to ensure proper prostheses engraftment. Noninvasive imaging modalities are fundamental to control the remodeling and function of biohybrid tissue‐engineered vascular grafts, which is particularly true for the critical transition time between late in vitro maturation and early in vivo engraftment. Here, a noninvasive multimodal, molecular imaging concept is presented to longitudinally monitor textile scaffold resorption, extracellular matrix remodeling, and endothelial inflammation. Tissue‐engineered vascular grafts (TEVGs) with the ability to grow and remodel open new perspectives for cardiovascular surgery. Equipping TEVGs with synthetic polymers and biological components provides a good compromise between high structural stability and biological adaptability. However, imaging approaches to control grafts’ structural integrity, physiological function, and remodeling during the entire transition between late in vitro maturation and early in vivo engraftment are mandatory for clinical implementation. Thus, a comprehensive molecular imaging concept using magnetic resonance imaging (MRI) and ultrasound (US) to monitor textile scaffold resorption, extracellular matrix (ECM) remodeling, and endothelial integrity in TEVGs is presented here. Superparamagnetic iron‐oxide nanoparticles (SPION) incorporated in biodegradable poly(lactic‐ co ‐glycolic acid) (PLGA) fibers of the TEVGs allow to quantitatively monitor scaffold resorption via MRI both in vitro and in vivo. Additionally, ECM formation can be depicted by molecular MRI using elastin‐ and collagen‐targeted probes. Finally, molecular US of α v β 3 integrins confirms the absence of endothelial dysfunction; the latter is provocable by TNF‐ α . In conclusion, the successful employment of noninvasive molecular imaging to longitudinally evaluate TEVGs remodeling is demonstrated. This approach may foster its translation from in vitro quality control assessment to in vivo applications to ensure proper prostheses engraftment.
Author	Jockenhoevel, Stefan Mohapatra, Saurav Ranjan Dadfar, Seyed Mohammadali Brueck, Ramona Nolte, Teresa Rama, Elena Apel, Christian Kiessling, Fabian Rix, Anne Gries, Thomas Lammers, Twan Schulz, Volkmar Melcher, Christoph Pathak, Vertika
AuthorAffiliation	2 Department of Biohybrid & Medical Textiles Institute of Applied Medical Engineering RWTH – Aachen University Forckenbeckstrasse 55 52074 Aachen Germany 3 Institute for Textile Technology RWTH – Aachen University Forckenbeckstrasse 55 52074 Aachen Germany 1 Institute for Experimental Molecular Imaging University Clinic and Helmholtz Institute for Biomedical Engineering RWTH – Aachen University Forckenbeckstrasse 55 52074 Aachen Germany
AuthorAffiliation_xml	– name: 2 Department of Biohybrid & Medical Textiles Institute of Applied Medical Engineering RWTH – Aachen University Forckenbeckstrasse 55 52074 Aachen Germany – name: 1 Institute for Experimental Molecular Imaging University Clinic and Helmholtz Institute for Biomedical Engineering RWTH – Aachen University Forckenbeckstrasse 55 52074 Aachen Germany – name: 3 Institute for Textile Technology RWTH – Aachen University Forckenbeckstrasse 55 52074 Aachen Germany
Author_xml	– sequence: 1 givenname: Elena orcidid: 0000-0002-4445-3541 surname: Rama fullname: Rama, Elena organization: Institute for Experimental Molecular Imaging University Clinic and Helmholtz Institute for Biomedical Engineering RWTH – Aachen University Forckenbeckstrasse 55 – sequence: 2 givenname: Saurav Ranjan surname: Mohapatra fullname: Mohapatra, Saurav Ranjan organization: Institute of Applied Medical Engineering RWTH – Aachen University Forckenbeckstrasse 55 – sequence: 3 givenname: Christoph surname: Melcher fullname: Melcher, Christoph organization: Institute for Textile Technology RWTH – Aachen University Forckenbeckstrasse 55 – sequence: 4 givenname: Teresa surname: Nolte fullname: Nolte, Teresa organization: Institute for Experimental Molecular Imaging University Clinic and Helmholtz Institute for Biomedical Engineering RWTH – Aachen University Forckenbeckstrasse 55 – sequence: 5 givenname: Seyed Mohammadali surname: Dadfar fullname: Dadfar, Seyed Mohammadali organization: Institute for Experimental Molecular Imaging University Clinic and Helmholtz Institute for Biomedical Engineering RWTH – Aachen University Forckenbeckstrasse 55 – sequence: 6 givenname: Ramona surname: Brueck fullname: Brueck, Ramona organization: Institute for Experimental Molecular Imaging University Clinic and Helmholtz Institute for Biomedical Engineering RWTH – Aachen University Forckenbeckstrasse 55 – sequence: 7 givenname: Vertika surname: Pathak fullname: Pathak, Vertika organization: Institute for Experimental Molecular Imaging University Clinic and Helmholtz Institute for Biomedical Engineering RWTH – Aachen University Forckenbeckstrasse 55 – sequence: 8 givenname: Anne surname: Rix fullname: Rix, Anne organization: Institute for Experimental Molecular Imaging University Clinic and Helmholtz Institute for Biomedical Engineering RWTH – Aachen University Forckenbeckstrasse 55 – sequence: 9 givenname: Thomas surname: Gries fullname: Gries, Thomas organization: Institute for Textile Technology RWTH – Aachen University Forckenbeckstrasse 55 – sequence: 10 givenname: Volkmar surname: Schulz fullname: Schulz, Volkmar organization: Institute for Experimental Molecular Imaging University Clinic and Helmholtz Institute for Biomedical Engineering RWTH – Aachen University Forckenbeckstrasse 55 – sequence: 11 givenname: Twan surname: Lammers fullname: Lammers, Twan organization: Institute for Experimental Molecular Imaging University Clinic and Helmholtz Institute for Biomedical Engineering RWTH – Aachen University Forckenbeckstrasse 55 – sequence: 12 givenname: Christian surname: Apel fullname: Apel, Christian organization: Institute of Applied Medical Engineering RWTH – Aachen University Forckenbeckstrasse 55 – sequence: 13 givenname: Stefan surname: Jockenhoevel fullname: Jockenhoevel, Stefan organization: Institute of Applied Medical Engineering RWTH – Aachen University Forckenbeckstrasse 55 – sequence: 14 givenname: Fabian orcidid: 0000-0002-7341-0399 surname: Kiessling fullname: Kiessling, Fabian email: fkiessling@ukaachen.de organization: Institute for Experimental Molecular Imaging University Clinic and Helmholtz Institute for Biomedical Engineering RWTH – Aachen University Forckenbeckstrasse 55
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/35119216$$D View this record in MEDLINE/PubMed
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Cites_doi	10.1155/2013/390518 10.1016/j.actbio.2014.10.029 10.3109/15419069409014198 10.1097/RLI.0b013e31815a251b 10.1089/ten.tec.2013.0041 10.3109/02656736.2014.997809 10.1016/j.crad.2010.04.006 10.1088/1748-6041/6/5/055001 10.1016/S0945-053X(00)00080-9 10.1016/j.jacc.2019.10.009 10.1016/j.cub.2020.06.027 10.1016/j.biomaterials.2010.02.006 10.1016/j.biomaterials.2007.07.017 10.1016/j.cellsig.2019.109364 10.1002/anie.200700700 10.1016/S0741-5214(94)70127-X 10.1007/s10439-006-9099-3 10.1165/rcmb.2013-0039OC 10.3390/ijms21207541 10.1002/mabi.201700002 10.1039/C5NR01651G 10.1161/ATVBAHA.109.193185 10.1039/C5RA27791D 10.1021/acs.chemmater.6b04649 10.1172/JCI117718 10.1515/CCLM.2004.082 10.1016/j.biomaterials.2004.07.034 10.1007/s12221-012-0685-8 10.1016/j.ceb.2006.12.013 10.1096/fsb2fasebj.12.1.47 10.1161/CIR.0b013e3182009701 10.1006/excr.1994.1282 10.1002/jbm.a.10599 10.2741/1313 10.1016/j.cardiores.2007.04.018 10.1161/ATVBAHA.117.309503 10.1016/j.biomaterials.2021.120896 10.3390/nano10101935 10.2967/jnumed.113.128173 10.1242/dev.145672 10.1016/S0945-053X(03)00052-0 10.1089/ten.2006.12.2765 10.1097/RLI.0000000000000282 10.1016/j.biomaterials.2010.02.051 10.1055/s-0037-1615250 10.1016/j.jcmg.2011.06.019 10.1038/nrm2820 10.1177/1535370212473700 10.1161/ATVBAHA.114.304857 10.1016/j.jacc.2020.11.010 10.1016/j.biomaterials.2012.06.018 10.1093/eurheartj/ehq413 10.1016/j.biomaterials.2019.119228 10.1007/s00403-006-0713-x 10.1172/JCI13005 10.1152/ajpcell.00064.2002 10.1021/acsomega.9b01544 10.1182/blood-2014-06-528406 10.1016/j.ijcard.2013.07.165 10.1016/j.biomaterials.2005.06.024 10.1007/978-3-030-05336-9_13 10.1039/C8NR00703A 10.3390/polym3031377 10.1016/j.biomaterials.2014.10.076 10.3389/fbioe.2019.00340 10.1038/nm.2310 10.1038/s41598-021-90092-y 10.1016/j.biomaterials.2004.04.036 10.1016/j.coph.2014.08.002 10.1263/jbb.106.515 10.1593/neo.09540 10.1002/adfm.201301275
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Copyright	2022 The Authors. Advanced Science published by Wiley‐VCH GmbH 2022 The Authors. Advanced Science published by Wiley-VCH GmbH. 2022. This work is published under http://creativecommons.org/licenses/by/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
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Keywords	poly(lactic-co-glycolic acid) superparamagnetic iron-oxide nanoparticles tissue-engineering molecular imaging αvβ3 integrins
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References	2015; 35 2010; 11 1990; 10 2015; 39 1994; 214 2019; 11 2015; 31 2004; 26 2013; 168 2014; 24 2008; 106 1998; 80 2020; 10 2005; 26 2011; 17 2007; 75 2012; 13 2001; 107 2007; 35 2014; 20 2007; 28 2009; 11 2010; 65 2013; 2013 2019; 63 2006; 27 2007; 298 2013; 238 2014; 18 2021; 275 2011; 123 1998; 12 2018; 38 2014; 55 2019; 7 2015; 12 1995; 95 2007; 19 2010; 31 2004; 42 2019; 4 2013; 49 2006; 12 2019; 74 2015; 125 2000; 22 2016; 51 2011; 32 2017; 29 2020; 76 2011; 4 2011; 3 2011; 6 2012; 33 2015; 7 2009; 29 2016; 6 2021; 11 1994; 19 2020; 30 2002; 283 2017; 17 2020 2019; 138 2016 2008; 43 2019; 216 2020; 21 2017; 144 2018; 10 1994; 2 2007; 46 2003; 22 2003; 67 e_1_2_8_28_1 e_1_2_8_24_1 e_1_2_8_47_1 e_1_2_8_26_1 e_1_2_8_49_1 e_1_2_8_68_1 Appold L. (e_1_2_8_62_1) 2017; 17 e_1_2_8_3_1 e_1_2_8_5_1 e_1_2_8_7_1 e_1_2_8_9_1 e_1_2_8_20_1 e_1_2_8_43_1 e_1_2_8_66_1 e_1_2_8_22_1 e_1_2_8_45_1 e_1_2_8_64_1 Sutcliffe M. C. (e_1_2_8_48_1) 1990; 10 e_1_2_8_1_1 e_1_2_8_41_1 e_1_2_8_60_1 e_1_2_8_17_1 e_1_2_8_19_1 e_1_2_8_13_1 e_1_2_8_36_1 e_1_2_8_59_1 Talacua H. (e_1_2_8_58_1) 2016 e_1_2_8_15_1 e_1_2_8_38_1 e_1_2_8_57_1 e_1_2_8_70_1 e_1_2_8_32_1 e_1_2_8_11_1 e_1_2_8_34_1 e_1_2_8_53_1 e_1_2_8_76_1 e_1_2_8_51_1 e_1_2_8_74_1 e_1_2_8_30_1 e_1_2_8_29_1 e_1_2_8_25_1 e_1_2_8_46_1 Mohammadali S. (e_1_2_8_72_1) 2019; 138 e_1_2_8_27_1 e_1_2_8_69_1 e_1_2_8_2_1 e_1_2_8_4_1 e_1_2_8_6_1 Sun Q. (e_1_2_8_55_1) 2019; 11 e_1_2_8_8_1 e_1_2_8_21_1 e_1_2_8_42_1 e_1_2_8_67_1 e_1_2_8_23_1 e_1_2_8_44_1 e_1_2_8_65_1 e_1_2_8_63_1 e_1_2_8_40_1 e_1_2_8_61_1 e_1_2_8_18_1 e_1_2_8_39_1 e_1_2_8_14_1 e_1_2_8_35_1 e_1_2_8_16_1 e_1_2_8_37_1 e_1_2_8_10_1 e_1_2_8_31_1 e_1_2_8_56_1 e_1_2_8_12_1 e_1_2_8_33_1 e_1_2_8_54_1 e_1_2_8_75_1 e_1_2_8_52_1 e_1_2_8_73_1 e_1_2_8_50_1 e_1_2_8_71_1
References_xml	– volume: 3 start-page: 1377 year: 2011 publication-title: Polymers – volume: 10 start-page: 148 year: 1990 publication-title: Matrix Collagen Relat. Res. – volume: 20 start-page: 177 year: 2014 publication-title: Tissue Eng., Part C Methods – volume: 55 start-page: 392 year: 2014 publication-title: J. Nucl. Med. – volume: 31 start-page: 4672 year: 2010 publication-title: Biomaterials – volume: 10 start-page: 8226 year: 2018 publication-title: Nanoscale – volume: 4 start-page: 1171 year: 2011 publication-title: JACC Cardiovasc. Imaging – volume: 10 start-page: 1935 year: 2020 publication-title: Nanomaterials – volume: 65 start-page: 557 year: 2010 publication-title: Clin. Radiol. – volume: 63 year: 2019 publication-title: Cell. Signalling – volume: 29 start-page: 2125 year: 2009 publication-title: Arterioscler., Thromb., Vasc. Biol. – volume: 42 start-page: 475 year: 2004 publication-title: Clin. Chem. Lab. Med. – volume: 38 start-page: 40 year: 2018 publication-title: Arterioscler., Thromb., Vasc. Biol. – volume: 22 start-page: 339 year: 2003 publication-title: Matrix Biol. – volume: 12 start-page: 47 year: 1998 publication-title: FASEB J. – volume: 125 start-page: 2019 year: 2015 publication-title: Blood – volume: 238 start-page: 176 year: 2013 publication-title: Exp. Biol. Med. – volume: 7 start-page: 340 year: 2019 publication-title: Front. Bioeng. Biotechnol. – volume: 138 start-page: 302 year: 2019 publication-title: J., Nanobiotechnol. – volume: 17 start-page: 1 year: 2017 publication-title: Macromol. Biosci. – volume: 106 start-page: 515 year: 2008 publication-title: J. Biosci. Bioeng. – volume: 49 start-page: 1120 year: 2013 publication-title: Am. J. Respir. Cell Mol. Biol. – volume: 67 start-page: 295 year: 2003 publication-title: J. Biomed. Mater. Res., Part A – volume: 80 start-page: 726 year: 1998 publication-title: Thromb. Haemostasis – volume: 21 start-page: 7541 year: 2020 publication-title: Int. J. Mol. Sci. – volume: 29 start-page: 2669 year: 2017 publication-title: Chem. Mater. – volume: 31 start-page: 90 year: 2015 publication-title: Int. J. Hyperthermia – volume: 26 start-page: 1422 year: 2004 publication-title: Front. Biosci. – volume: 26 start-page: 2559 year: 2005 publication-title: Biomaterials – volume: 2 start-page: 7 year: 1994 publication-title: Cell Commun. Adhes. – volume: 11 start-page: 856 year: 2009 publication-title: Neoplasia – volume: 19 start-page: 125 year: 1994 publication-title: J. Vasc. Surg. – volume: 75 start-page: 618 year: 2007 publication-title: Cardiovasc. Res. – volume: 11 start-page: 1 year: 2019 publication-title: Sci. Transl. Med. – volume: 74 start-page: 2529 year: 2019 publication-title: J. Am. Coll. Cardiol. – volume: 31 start-page: 4731 year: 2010 publication-title: Biomaterials – volume: 19 start-page: 43 year: 2007 publication-title: Curr. Opin. Cell Biol. – volume: 12 start-page: 2765 year: 2006 publication-title: Tissue Eng. – volume: 51 start-page: 767 year: 2016 publication-title: Invest. Radiol. – volume: 11 year: 2021 publication-title: Sci. Rep. – volume: 35 start-page: 190 year: 2007 publication-title: Ann. Biomed. Eng. – volume: 24 start-page: 754 year: 2014 publication-title: Adv. Funct. Mater. – volume: 144 start-page: 869 year: 2017 publication-title: Development – volume: 283 start-page: C1196 year: 2002 publication-title: Am. J. Physiol. ‐ Cell Physiol. – volume: 95 start-page: 713 year: 1995 publication-title: J. Clin. Invest. – volume: 6 year: 2011 publication-title: Biomed. Mater. – volume: 168 start-page: 5028 year: 2013 publication-title: Int. J. Cardiol. – year: 2016 – volume: 43 start-page: 162 year: 2008 publication-title: Invest. Radiol. – volume: 6 year: 2016 publication-title: RSC Adv. – volume: 11 start-page: 50 year: 2010 publication-title: Nat. Rev. Mol. Cell Biol. – volume: 22 start-page: 353 year: 2000 publication-title: Matrix Biol. – volume: 2013 start-page: 1 year: 2013 publication-title: Biomed Res. Int. – volume: 17 start-page: 383 year: 2011 publication-title: Nat. Med. – volume: 4 year: 2019 publication-title: ACS Omega – volume: 32 start-page: 1561 year: 2011 publication-title: Eur. Heart J. – volume: 216 year: 2019 publication-title: Biomaterials – volume: 33 start-page: 6604 year: 2012 publication-title: Biomaterials – volume: 39 start-page: 155 year: 2015 publication-title: Biomaterials – volume: 28 start-page: 5009 year: 2007 publication-title: Biomaterials – volume: 18 start-page: 18 year: 2014 publication-title: Curr. Opin. Pharmacol. – volume: 107 start-page: 1209 year: 2001 publication-title: J. Clin. Invest. – volume: 27 start-page: 724 year: 2006 publication-title: Biomaterials – volume: 275 year: 2021 publication-title: Biomaterials – volume: 46 start-page: 8171 year: 2007 publication-title: Angew. Chem., Int. Ed. – volume: 12 start-page: 146 year: 2015 publication-title: Acta Biomater. – volume: 30 start-page: 3316 year: 2020 publication-title: Curr. Biol. – year: 2020 – volume: 26 start-page: 1405 year: 2005 publication-title: Biomaterials – volume: 13 start-page: 685 year: 2012 publication-title: Fibers Polym. – volume: 298 start-page: 413 year: 2007 publication-title: Arch. Dermatol. Res. – volume: 7 year: 2015 publication-title: Nanoscale – volume: 35 start-page: 1366 year: 2015 publication-title: Arterioscler., Thromb., Vasc. Biol. – volume: 76 start-page: 2982 year: 2020 publication-title: J. Am. Coll. Cardiol. – volume: 214 start-page: 459 year: 1994 publication-title: Exp. Cell Res. – volume: 123 start-page: 18 year: 2011 publication-title: Circulation – ident: e_1_2_8_8_1 doi: 10.1155/2013/390518 – ident: e_1_2_8_34_1 doi: 10.1016/j.actbio.2014.10.029 – ident: e_1_2_8_65_1 doi: 10.3109/15419069409014198 – ident: e_1_2_8_74_1 doi: 10.1097/RLI.0b013e31815a251b – ident: e_1_2_8_57_1 doi: 10.1089/ten.tec.2013.0041 – ident: e_1_2_8_13_1 doi: 10.3109/02656736.2014.997809 – ident: e_1_2_8_12_1 doi: 10.1016/j.crad.2010.04.006 – ident: e_1_2_8_9_1 doi: 10.1088/1748-6041/6/5/055001 – volume-title: In Situ Cardiovascular Tissue Engineering year: 2016 ident: e_1_2_8_58_1 contributor: fullname: Talacua H. – ident: e_1_2_8_24_1 doi: 10.1016/S0945-053X(00)00080-9 – ident: e_1_2_8_2_1 doi: 10.1016/j.jacc.2019.10.009 – ident: e_1_2_8_47_1 doi: 10.1016/j.cub.2020.06.027 – ident: e_1_2_8_59_1 doi: 10.1016/j.biomaterials.2010.02.006 – ident: e_1_2_8_7_1 doi: 10.1016/j.biomaterials.2007.07.017 – ident: e_1_2_8_46_1 doi: 10.1016/j.cellsig.2019.109364 – ident: e_1_2_8_26_1 doi: 10.1002/anie.200700700 – ident: e_1_2_8_39_1 doi: 10.1016/S0741-5214(94)70127-X – ident: e_1_2_8_37_1 doi: 10.1007/s10439-006-9099-3 – ident: e_1_2_8_56_1 doi: 10.1165/rcmb.2013-0039OC – ident: e_1_2_8_22_1 doi: 10.3390/ijms21207541 – volume: 17 start-page: 1 year: 2017 ident: e_1_2_8_62_1 publication-title: Macromol. Biosci. doi: 10.1002/mabi.201700002 contributor: fullname: Appold L. – ident: e_1_2_8_73_1 doi: 10.1039/C5NR01651G – ident: e_1_2_8_67_1 doi: 10.1161/ATVBAHA.109.193185 – ident: e_1_2_8_18_1 doi: 10.1039/C5RA27791D – ident: e_1_2_8_51_1 doi: 10.1021/acs.chemmater.6b04649 – volume: 11 start-page: 1 year: 2019 ident: e_1_2_8_55_1 publication-title: Sci. Transl. Med. contributor: fullname: Sun Q. – ident: e_1_2_8_41_1 doi: 10.1172/JCI117718 – ident: e_1_2_8_64_1 doi: 10.1515/CCLM.2004.082 – ident: e_1_2_8_21_1 doi: 10.1016/j.biomaterials.2004.07.034 – ident: e_1_2_8_17_1 doi: 10.1007/s12221-012-0685-8 – ident: e_1_2_8_45_1 doi: 10.1016/j.ceb.2006.12.013 – ident: e_1_2_8_31_1 doi: 10.1096/fsb2fasebj.12.1.47 – ident: e_1_2_8_3_1 doi: 10.1161/CIR.0b013e3182009701 – ident: e_1_2_8_40_1 doi: 10.1006/excr.1994.1282 – ident: e_1_2_8_29_1 doi: 10.1002/jbm.a.10599 – ident: e_1_2_8_35_1 doi: 10.2741/1313 – ident: e_1_2_8_32_1 doi: 10.1016/j.cardiores.2007.04.018 – ident: e_1_2_8_71_1 doi: 10.1161/ATVBAHA.117.309503 – ident: e_1_2_8_76_1 doi: 10.1016/j.biomaterials.2021.120896 – ident: e_1_2_8_14_1 doi: 10.3390/nano10101935 – ident: e_1_2_8_6_1 doi: 10.2967/jnumed.113.128173 – ident: e_1_2_8_68_1 doi: 10.1242/dev.145672 – ident: e_1_2_8_23_1 doi: 10.1016/S0945-053X(03)00052-0 – ident: e_1_2_8_53_1 doi: 10.1089/ten.2006.12.2765 – ident: e_1_2_8_42_1 doi: 10.1097/RLI.0000000000000282 – ident: e_1_2_8_30_1 doi: 10.1016/j.biomaterials.2010.02.051 – ident: e_1_2_8_44_1 doi: 10.1055/s-0037-1615250 – ident: e_1_2_8_52_1 doi: 10.1016/j.jcmg.2011.06.019 – ident: e_1_2_8_20_1 doi: 10.1038/nrm2820 – ident: e_1_2_8_70_1 doi: 10.1177/1535370212473700 – ident: e_1_2_8_61_1 doi: 10.1161/ATVBAHA.114.304857 – volume: 10 start-page: 148 year: 1990 ident: e_1_2_8_48_1 publication-title: Matrix Collagen Relat. Res. contributor: fullname: Sutcliffe M. C. – ident: e_1_2_8_1_1 doi: 10.1016/j.jacc.2020.11.010 – ident: e_1_2_8_11_1 doi: 10.1016/j.biomaterials.2012.06.018 – ident: e_1_2_8_54_1 doi: 10.1093/eurheartj/ehq413 – ident: e_1_2_8_4_1 doi: 10.1016/j.biomaterials.2019.119228 – ident: e_1_2_8_19_1 doi: 10.1007/s00403-006-0713-x – ident: e_1_2_8_66_1 doi: 10.1172/JCI13005 – ident: e_1_2_8_43_1 doi: 10.1152/ajpcell.00064.2002 – ident: e_1_2_8_63_1 doi: 10.1021/acsomega.9b01544 – ident: e_1_2_8_69_1 doi: 10.1182/blood-2014-06-528406 – ident: e_1_2_8_5_1 doi: 10.1016/j.ijcard.2013.07.165 – ident: e_1_2_8_25_1 doi: 10.1016/j.biomaterials.2005.06.024 – ident: e_1_2_8_36_1 doi: 10.1007/978-3-030-05336-9_13 – ident: e_1_2_8_50_1 doi: 10.1039/C8NR00703A – volume: 138 start-page: 302 year: 2019 ident: e_1_2_8_72_1 publication-title: J., Nanobiotechnol. contributor: fullname: Mohammadali S. – ident: e_1_2_8_10_1 doi: 10.3390/polym3031377 – ident: e_1_2_8_15_1 doi: 10.1016/j.biomaterials.2014.10.076 – ident: e_1_2_8_33_1 doi: 10.3389/fbioe.2019.00340 – ident: e_1_2_8_27_1 doi: 10.1038/nm.2310 – ident: e_1_2_8_28_1 doi: 10.1038/s41598-021-90092-y – ident: e_1_2_8_38_1 doi: 10.1016/j.biomaterials.2004.04.036 – ident: e_1_2_8_49_1 doi: 10.1016/j.coph.2014.08.002 – ident: e_1_2_8_60_1 doi: 10.1263/jbb.106.515 – ident: e_1_2_8_75_1 doi: 10.1593/neo.09540 – ident: e_1_2_8_16_1 doi: 10.1002/adfm.201301275
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Snippet	Tissue‐engineered vascular grafts (TEVGs) with the ability to grow and remodel open new perspectives for cardiovascular surgery. Equipping TEVGs with synthetic... Tissue-engineered vascular grafts (TEVGs) with the ability to grow and remodel open new perspectives for cardiovascular surgery. Equipping TEVGs with synthetic... Abstract Tissue‐engineered vascular grafts (TEVGs) with the ability to grow and remodel open new perspectives for cardiovascular surgery. Equipping TEVGs with...
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SubjectTerms	Biocompatibility Biodegradation Blood Vessel Prosthesis Collagen Extracellular Matrix Magnetic resonance imaging Molecular Imaging Nanoparticles poly(lactic‐co‐glycolic acid) Prostheses superparamagnetic iron‐oxide nanoparticles Synthetic products Tissue Engineering - methods tissue‐engineering Transplants & implants Ultrasonic imaging αvβ3 integrins
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Title	Monitoring the Remodeling of Biohybrid Tissue‐Engineered Vascular Grafts by Multimodal Molecular Imaging
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