Awakening, Clinical Recovery, and Psychomotor Effects After Desflurane and Propofol Anesthesia

• Published in: Anesthesia and analgesia Vol. 83; no. 4; pp. 721 - 725
• Main Authors: Apfelbaum, Jeffrey L., Lichtor, J. Lance, Lane, Bradford S., Coalson, Dennis W., Korttila, Kari T.
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD International Anesthesia Research Society 01-10-1996; Lippincott
• Subjects: Adult; Anesthesia Recovery Period; Anesthesia, Inhalation; Anesthesia, Intravenous; Anesthetics, Inhalation - administration & dosage; Anesthetics, Inhalation - pharmacology; Anesthetics, Intravenous - administration & dosage; Anesthetics, Intravenous - pharmacology; Anesthetics. Neuromuscular blocking agents; Attention - drug effects; Biological and medical sciences; Cross-Over Studies; Desflurane; Follow-Up Studies; Humans; Isoflurane - administration & dosage; Isoflurane - analogs & derivatives; Isoflurane - pharmacology; Medical sciences; Memory - drug effects; Motor Skills - drug effects; Neuropharmacology; Nitrous Oxide - administration & dosage; Oxygen - administration & dosage; Patient Discharge; Pharmacology. Drug treatments; Propofol - administration & dosage; Propofol - pharmacology; Prospective Studies; Psychomotor Performance - drug effects; Wakefulness - drug effects; Volatile compound; Human; Intravenous administration; General anesthetic; General anesthesia; Fluorine Organic compounds; Recovery; Comparative study
• ISSN: 0003-2999; 1526-7598
• DOI: 10.1097/00000539-199610000-00010

We compared postanesthetic and residual recovery of desflurane versus propofol anesthesia.Twenty volunteers were anesthetized for 1 h at 1-wk intervals with either propofol (induction) plus desflurane (1.25 minimum alveolar anesthetic concentration) in O2 (PD), propofol plus desflurane in N2 O-O2 (PDN), propofol plus propofol infusion with N2 O-O2 (PPN), or desflurane (induction) plus desflurane in O2 (DD). Awakening and clinical recovery were measured. Psychomotor skills (attention, coordination, reactive skills, and memory) were tested before and 1, 3, 5, and 7 h after anesthesia. Awakening was fastest in Group PDN. At 1 h after anesthesia, the subjects given desflurane for maintenance (PD, PDN, and DD) performed significantly (P < 0.05-0.01) better in several psychomotor tests compared with those whose anesthesia was maintained with propofol (PPN). However, subjects met criteria for home readiness as fast after PPN as after PDN anesthesia (mean times +/- SE until fitness for discharge were 126 +/- 20, 81 +/- 14, 70 +/- 7, and 106 +/- 14 min after PD, PDN, PPN, and DD, respectively). Awakening and early psychomotor recovery for as long as 1 h after anesthesia is faster after desflurane than after propofol, but there was no difference in time to home readiness or in residual effects thereafter between propofol and desflurane with N2 O in O2.(Anesth Analg 1996;83:721-5)