Antibiotic resistance free plasmid DNA expressing LACK protein leads towards a protective Th1 response against Leishmania infantum infection

Abstract Canine visceral leishmaniasis is a serious public health concern in the Mediterranean basin since dogs are the main Leishmania infantum reservoir. However, there is not a vaccination method in veterinary use in this area, and therefore the development of a vaccine against this parasite is e...

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Bibliographic Details
Published in:	Vaccine Vol. 27; no. 48; pp. 6695 - 6703
Main Authors:	Ramos, I, Alonso, A, Peris, A, Marcen, J.M, Abengozar, M.A, Alcolea, P.J, Castillo, J.A, Larraga, V
Format:	Journal Article
Language:	English
Published:	Kidlington Elsevier Ltd 12-11-2009 Elsevier
Subjects:	Allergy and Immunology Animals Antibiotic resistance Antibiotic resistance free DNA vaccine Antibodies, Protozoan - blood Antigens, Protozoan - immunology Applied microbiology Biological and medical sciences Canine visceral leishmaniasis Cytokines - immunology DNA, Protozoan - immunology Dog Diseases - immunology Dog Diseases - prevention & control Dogs Female Fundamental and applied biological sciences. Psychology Human protozoal diseases Immunization, Secondary Immunoglobulin G - blood Infectious diseases LACK Leishmania infantum Leishmania infantum - immunology Leishmaniasis Vaccines - immunology Leishmaniasis, Visceral - immunology Leishmaniasis, Visceral - prevention & control Leishmaniasis, Visceral - veterinary Leshmaniasis Liver - parasitology Lymphocyte Activation Male Medical sciences Microbiology Miscellaneous Modified vaccinia virus Ankara Parasitic diseases Plasmids Protozoal diseases Protozoan Proteins - immunology Th1 Cells - immunology Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects) Vaccines, DNA - immunology Virology Leishmania infantum Modified vaccinia virus Ankara LACK Antibiotic resistance free DNA vaccine Canine visceral leishmaniasis Protozoal disease Th1 lymphocyte Helper cell Kala azar T-Lymphocyte Dog Kinetoplastida Fissipedia Protozoa Carnivora Chordopoxvirinae Orthopoxvirus Leishmaniasis Parasitosis Genetic vaccine Protein Infection Virus Plasmid Resistance Vaccinia virus Vertebrata Antibiotic Mammalia Poxviridae Veterinary
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