A Galacto-Oligosaccharides Preparation Derived From Lactulose Protects Against Colorectal Cancer Development in an Animal Model

Colorectal cancer (CRC) is one of the most common neoplasias worldwide, and its incidence is increasing. Consumption of prebiotics is a useful strategy in order to prevent this important disease. These nutraceutical compounds might exert protective biological functions as antitumors. In order to tes...

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Published in:	Frontiers in microbiology Vol. 9; p. 2004
Main Authors:	Fernández, Javier, Moreno, F J, Olano, Agustín, Clemente, Alfonso, Villar, Claudio J, Lombó, Felipe
Format:	Journal Article
Language:	English
Published:	Switzerland Frontiers Media S.A 31-08-2018
Subjects:	colorectal cancer galacto-oligosaccharides gut microbiota Microbiology prebiotic prevention colorectal cancer prebiotic gut microbiota prevention galacto-oligosaccharides
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Abstract	Colorectal cancer (CRC) is one of the most common neoplasias worldwide, and its incidence is increasing. Consumption of prebiotics is a useful strategy in order to prevent this important disease. These nutraceutical compounds might exert protective biological functions as antitumors. In order to test the chemopreventive effect of GOS-Lu (galacto-oligosaccharides derived from lactulose) prebiotic preparation against this cancer, an animal model ( F344) was used. In this model, two doses of azoxymethane (10 mg/kg) and two treatments with dextran sodium sulfate (DSS) were administered to the animals. Animals were fed for 20 weeks, and either control drinking water or drinking water containing 10% (w/w) GOS-Lu prebiotic preparation was provided to them. Animals were sacrificed after those 20 weeks, and their digestive tract tissues were analyzed. The results revealed a statistically significant reduction in the number of colon tumors in the GOS-Lu cohort with respect to control animals. Metagenomics sequencing was used for studying colon microbiota populations, revealing significant reductions in populations of pro-inflammatory bacteria families and species, and significant increases in interesting beneficial populations, such as . Therefore, oral administration of the prebiotic GOS-Lu preparation may be an effective strategy for preventing CRC.
AbstractList	Colorectal cancer (CRC) is one of the most common neoplasias worldwide, and its incidence is increasing. Consumption of prebiotics is a useful strategy in order to prevent this important disease. These nutraceutical compounds might exert protective biological functions as antitumors. In order to test the chemopreventive effect of GOS-Lu (galacto-oligosaccharides derived from lactulose) prebiotic preparation against this cancer, an animal model ( Rattus norvegicus F344) was used. In this model, two doses of azoxymethane (10 mg/kg) and two treatments with dextran sodium sulfate (DSS) were administered to the animals. Animals were fed for 20 weeks, and either control drinking water or drinking water containing 10% (w/w) GOS-Lu prebiotic preparation was provided to them. Animals were sacrificed after those 20 weeks, and their digestive tract tissues were analyzed. The results revealed a statistically significant reduction in the number of colon tumors in the GOS-Lu cohort with respect to control animals. Metagenomics sequencing was used for studying colon microbiota populations, revealing significant reductions in populations of pro-inflammatory bacteria families and species, and significant increases in interesting beneficial populations, such as Bifidobacterium . Therefore, oral administration of the prebiotic GOS-Lu preparation may be an effective strategy for preventing CRC. Colorectal cancer (CRC) is one of the most common neoplasias worldwide, and its incidence is increasing. Consumption of prebiotics is a useful strategy in order to prevent this important disease. These nutraceutical compounds might exert protective biological functions as antitumors. In order to test the chemopreventive effect of GOS-Lu (galacto-oligosaccharides derived from lactulose) prebiotic preparation against this cancer, an animal model (Rattus norvegicus F344) was used. In this model, two doses of azoxymethane (10 mg/kg) and two treatments with dextran sodium sulfate (DSS) were administered to the animals. Animals were fed for 20 weeks, and either control drinking water or drinking water containing 10% (w/w) GOS-Lu prebiotic preparation was provided to them. Animals were sacrificed after those 20 weeks, and their digestive tract tissues were analyzed. The results revealed a statistically significant reduction in the number of colon tumors in the GOS-Lu cohort with respect to control animals. Metagenomics sequencing was used for studying colon microbiota populations, revealing significant reductions in populations of pro-inflammatory bacteria families and species, and significant increases in interesting beneficial populations, such as Bifidobacterium. Therefore, oral administration of the prebiotic GOS-Lu preparation may be an effective strategy for preventing CRC. Colorectal cancer (CRC) is one of the most common neoplasias worldwide, and its incidence is increasing. Consumption of prebiotics is a useful strategy in order to prevent this important disease. These nutraceutical compounds might exert protective biological functions as antitumors. In order to test the chemopreventive effect of GOS-Lu (galacto-oligosaccharides derived from lactulose) prebiotic preparation against this cancer, an animal model ( F344) was used. In this model, two doses of azoxymethane (10 mg/kg) and two treatments with dextran sodium sulfate (DSS) were administered to the animals. Animals were fed for 20 weeks, and either control drinking water or drinking water containing 10% (w/w) GOS-Lu prebiotic preparation was provided to them. Animals were sacrificed after those 20 weeks, and their digestive tract tissues were analyzed. The results revealed a statistically significant reduction in the number of colon tumors in the GOS-Lu cohort with respect to control animals. Metagenomics sequencing was used for studying colon microbiota populations, revealing significant reductions in populations of pro-inflammatory bacteria families and species, and significant increases in interesting beneficial populations, such as . Therefore, oral administration of the prebiotic GOS-Lu preparation may be an effective strategy for preventing CRC.
Author	Moreno, F J Olano, Agustín Clemente, Alfonso Villar, Claudio J Fernández, Javier Lombó, Felipe
AuthorAffiliation	1 Research Unit “Biotechnology in Nutraceuticals and Bioactive Compounds-BIONUC”, Departamento de Biología Funcional, Área de Microbiología, Universidad de Oviedo , Oviedo , Spain 4 Instituto de Investigación en Ciencias de la Alimentación (CIAL-CSIC) , Madrid , Spain 2 Instituto Universitario de Oncología del Principado de Asturias , Oviedo , Spain 3 Instituto de Investigación Sanitaria del Principado de Asturias , Oviedo , Spain 5 Estación Experimental del Zaidín (EEZ-CSIC) , Granada , Spain
AuthorAffiliation_xml	– name: 5 Estación Experimental del Zaidín (EEZ-CSIC) , Granada , Spain – name: 3 Instituto de Investigación Sanitaria del Principado de Asturias , Oviedo , Spain – name: 4 Instituto de Investigación en Ciencias de la Alimentación (CIAL-CSIC) , Madrid , Spain – name: 2 Instituto Universitario de Oncología del Principado de Asturias , Oviedo , Spain – name: 1 Research Unit “Biotechnology in Nutraceuticals and Bioactive Compounds-BIONUC”, Departamento de Biología Funcional, Área de Microbiología, Universidad de Oviedo , Oviedo , Spain
Author_xml	– sequence: 1 givenname: Javier surname: Fernández fullname: Fernández, Javier organization: Instituto de Investigación Sanitaria del Principado de Asturias, Oviedo, Spain – sequence: 2 givenname: F J surname: Moreno fullname: Moreno, F J organization: Instituto de Investigación en Ciencias de la Alimentación (CIAL-CSIC), Madrid, Spain – sequence: 3 givenname: Agustín surname: Olano fullname: Olano, Agustín organization: Instituto de Investigación en Ciencias de la Alimentación (CIAL-CSIC), Madrid, Spain – sequence: 4 givenname: Alfonso surname: Clemente fullname: Clemente, Alfonso organization: Estación Experimental del Zaidín (EEZ-CSIC), Granada, Spain – sequence: 5 givenname: Claudio J surname: Villar fullname: Villar, Claudio J organization: Instituto de Investigación Sanitaria del Principado de Asturias, Oviedo, Spain – sequence: 6 givenname: Felipe surname: Lombó fullname: Lombó, Felipe organization: Instituto de Investigación Sanitaria del Principado de Asturias, Oviedo, Spain
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Keywords	colorectal cancer prebiotic gut microbiota prevention galacto-oligosaccharides
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Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 Reviewed by: Carlos Vera Vera, Universidad de Santiago de Chile, Chile; Jose M. Bruno-Barcena, North Carolina State University, United States This article was submitted to Food Microbiology, a section of the journal Frontiers in Microbiology Edited by: Andrea Gomez-Zavaglia, Centro de Investigación y Desarrollo en Criotecnología de Alimentos (CIDCA), Argentina
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Snippet	Colorectal cancer (CRC) is one of the most common neoplasias worldwide, and its incidence is increasing. Consumption of prebiotics is a useful strategy in...
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Title	A Galacto-Oligosaccharides Preparation Derived From Lactulose Protects Against Colorectal Cancer Development in an Animal Model
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