Comparison of 4 Screening Methods for Detecting Fluoropyrimidine Toxicity Risk: Identification of the Most Effective, Cost-Efficient Method to Save Lives

Background: Fluoropyrimidines (FPs) carry around 20% risk of G3-5 toxicity and 0.2-1% risk of death, due to dihydropyrimidine dehydrogenase (DPD) deficiency. Several screening approaches exist for predicting toxicity, however there is ongoing debate over which method is best. This study compares 4 s...

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Bibliographic Details

Published in:	Dose-response Vol. 18; no. 3; p. 1559325820951367
Main Authors:	Capitain, Olivier, Seegers, Valérie, Metges, Jean-Philippe, Faroux, Roger, Stampfli, Claire, Ferec, Marc, Budnik, Tamara Matysiak, Senellart, Hélène, Rossi, Valérie, Blouin, Nadège, Dauvé, Jonathan, Campone, Mario
Format:	Journal Article
Language:	English
Published:	Los Angeles, CA SAGE Publications 01-07-2020 SAGE PUBLICATIONS, INC SAGE Publishing
Subjects:	Cancer therapies Health risk assessment Original Radiation therapy Toxicity toxicity risk assessment screening comparison DPD deficiency fluoropyrimidines
Online Access:	Get full text
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