Status of vaccine research and development for Shigella

Highlights • Shigella infections cause substantial mortality and morbidity in children and adults. • Results from animal studies and challenge models spur Shigella vaccine development. • Various immune mechanisms show potential for durable and protective mucosal response. • Several vaccines are bein...

Full description

Saved in:

Bibliographic Details
Published in:	Vaccine Vol. 34; no. 26; pp. 2887 - 2894
Main Authors:	Mani, Sachin, Wierzba, Thomas, Walker, Richard I
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier Ltd 03-06-2016 Elsevier Limited
Subjects:	Adjuvants Allergy and Immunology Animal models Animals Bacteria Biomedical Research - trends Clinical Trials as Topic Combined vaccines Diarrhea Diarrhea - microbiology Diarrhea - prevention & control Diarrheal disease Disease Models, Animal Drinking water Dysentery Dysentery, Bacillary - prevention & control Enteric vaccines Food sanitation Genes Humans Impact assessment Mortality Observational studies Pathogens R&D Research & development Sanitation Shigella Shigella Vaccines - therapeutic use Vaccines Vaccines, Conjugate - therapeutic use Vaccines, Subunit - therapeutic use Waterborne diseases South Asia Diarrheal disease Adjuvants Impact assessment Shigella Enteric vaccines Combined vaccines
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!

Description
Summary:	Highlights • Shigella infections cause substantial mortality and morbidity in children and adults. • Results from animal studies and challenge models spur Shigella vaccine development. • Various immune mechanisms show potential for durable and protective mucosal response. • Several vaccines are being evaluated either alone or in association with an adjuvant.
Bibliography:	ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-3 content type line 23 ObjectType-Review-1 ObjectType-Article-1 ObjectType-Feature-2
ISSN:	0264-410X 1873-2518
DOI:	10.1016/j.vaccine.2016.02.075