In-Depth Study of the Interaction, Sensitivity, and Gating Modulation by PUFAs on K + Channels; Interaction and New Targets

In-Depth Study of the Interaction, Sensitivity, and Gating Modulation by PUFAs on K + Channels; Interaction and New Targets

Voltage gated potassium channels (K ) are membrane proteins that allow selective flow of K ions in a voltage-dependent manner. These channels play an important role in several excitable cells as neurons, cardiomyocytes, and vascular smooth muscle. Over the last 20 years, it has been shown that omega...

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Published in:Frontiers in physiology Vol. 7; p. 578
Main Authors: Moreno, Cristina, de la Cruz, Alicia, Valenzuela, Carmen
Format: Journal Article
Language:English
Published: Switzerland Frontiers Media S.A 24-11-2016
Subjects:
K2P
KATP
KCA
Kv7.1
Physiology
PUFAs
Shaker K channels
KATP
lipoelectric hypothesis
K2P
KCA
Kv7.1
shaker K channels
PUFAs
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Abstract Voltage gated potassium channels (K ) are membrane proteins that allow selective flow of K ions in a voltage-dependent manner. These channels play an important role in several excitable cells as neurons, cardiomyocytes, and vascular smooth muscle. Over the last 20 years, it has been shown that omega-3 polyunsaturated fatty acids (PUFAs) enhance or decrease the activity of several cardiac K channels. PUFAs-dependent modulation of potassium ion channels has been reported to be cardioprotective. However, the precise cellular mechanism underlying the cardiovascular benefits remained unclear in part because new PUFAs targets and signaling pathways continue being discovered. In this review, we will focus on recent data available concerning the following aspects of the K channel modulation by PUFAs: (i) the exact residues involved in PUFAs-K channels interaction; (ii) the structural PUFAs determinants important for their effects on K channels; (iii) the mechanism of the gating modulation of K channels and, finally, (iv) the PUFAs modulation of a few new targets present in smooth muscle cells (SMC), K 1.1, K , and K channels, involved in vascular relaxation.
AbstractList Voltage gated potassium channels (K ) are membrane proteins that allow selective flow of K ions in a voltage-dependent manner. These channels play an important role in several excitable cells as neurons, cardiomyocytes, and vascular smooth muscle. Over the last 20 years, it has been shown that omega-3 polyunsaturated fatty acids (PUFAs) enhance or decrease the activity of several cardiac K channels. PUFAs-dependent modulation of potassium ion channels has been reported to be cardioprotective. However, the precise cellular mechanism underlying the cardiovascular benefits remained unclear in part because new PUFAs targets and signaling pathways continue being discovered. In this review, we will focus on recent data available concerning the following aspects of the K channel modulation by PUFAs: (i) the exact residues involved in PUFAs-K channels interaction; (ii) the structural PUFAs determinants important for their effects on K channels; (iii) the mechanism of the gating modulation of K channels and, finally, (iv) the PUFAs modulation of a few new targets present in smooth muscle cells (SMC), K 1.1, K , and K channels, involved in vascular relaxation.
Voltage gated potassium channels (K V ) are membrane proteins that allow selective flow of K + ions in a voltage-dependent manner. These channels play an important role in several excitable cells as neurons, cardiomyocytes, and vascular smooth muscle. Over the last 20 years, it has been shown that omega-3 polyunsaturated fatty acids (PUFAs) enhance or decrease the activity of several cardiac K V channels. PUFAs-dependent modulation of potassium ion channels has been reported to be cardioprotective. However, the precise cellular mechanism underlying the cardiovascular benefits remained unclear in part because new PUFAs targets and signaling pathways continue being discovered. In this review, we will focus on recent data available concerning the following aspects of the K V channel modulation by PUFAs: (i) the exact residues involved in PUFAs-K V channels interaction; (ii) the structural PUFAs determinants important for their effects on K V channels; (iii) the mechanism of the gating modulation of K V channels and, finally, (iv) the PUFAs modulation of a few new targets present in smooth muscle cells (SMC), K Ca 1.1, K 2P , and K ATP channels, involved in vascular relaxation.
Voltage gated potassium channels (Kv) are membrane proteins that allow selective flow of K+ ions in a voltage-dependent manner. These channels play an important role in several excitable cells as neurons, cardiomyocytes and vascular smooth muscle. Over the last 20 years, it has been shown that omega-3 polyunsaturated fatty acids (PUFAs) enhance or decrease the activity of several cardiac Kv channels. PUFAs-dependent modulation of potassium ion channels has been reported to be cardioprotective. However, the precise cellular mechanism underlying the cardiovascular benefits remained unclear in part because new PUFAs targets and signaling pathways continue being discovered. In this review, we will focus on recent data available concerning the following aspects of the Kv channel modulation by PUFAs: i) the exact residues involved in PUFAs-Kv channels interaction; ii) the structural PUFAs determinants important for their effects on Kv channels; iii) the mechanism of the gating modulation of KV channels and, finally, iv) the PUFAs modulation of a few new targets present in smooth muscle cells, KCa1.1, K2P and KATP channels, involved in vascular relaxation.
Author de la Cruz, Alicia
Valenzuela, Carmen
Moreno, Cristina
AuthorAffiliation 1 Department of Cardiology, Cardiovascular Research Institute Maastricht, Maastricht University Medical Centre Maastricht, Netherlands
2 Departamento de Modelos Experimentales de Enfermedades Humanas, Instituto de Investigaciones Biomédicas “Alberto Sols” CSIC - Universidad Autónoma de Madrid Madrid, Spain
AuthorAffiliation_xml – name: 1 Department of Cardiology, Cardiovascular Research Institute Maastricht, Maastricht University Medical Centre Maastricht, Netherlands
– name: 2 Departamento de Modelos Experimentales de Enfermedades Humanas, Instituto de Investigaciones Biomédicas “Alberto Sols” CSIC - Universidad Autónoma de Madrid Madrid, Spain
Author_xml – sequence: 1
  givenname: Cristina
  surname: Moreno
  fullname: Moreno, Cristina
  organization: Department of Cardiology, Cardiovascular Research Institute Maastricht, Maastricht University Medical Centre Maastricht, Netherlands
– sequence: 2
  givenname: Alicia
  surname: de la Cruz
  fullname: de la Cruz, Alicia
  organization: Departamento de Modelos Experimentales de Enfermedades Humanas, Instituto de Investigaciones Biomédicas "Alberto Sols" CSIC - Universidad Autónoma de Madrid Madrid, Spain
– sequence: 3
  givenname: Carmen
  surname: Valenzuela
  fullname: Valenzuela, Carmen
  organization: Departamento de Modelos Experimentales de Enfermedades Humanas, Instituto de Investigaciones Biomédicas "Alberto Sols" CSIC - Universidad Autónoma de Madrid Madrid, Spain
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Keywords KATP
lipoelectric hypothesis
K2P
KCA
Kv7.1
shaker K channels
PUFAs
Language English
License This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
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Reviewed by: David Naranjo, Universidad de Valparaíso, Chile; Luís MS Loura, University of Coimbra, Portugal
Edited by: Mauricio Antonio Retamal, Universidad del Desarrollo, Chile
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Snippet Voltage gated potassium channels (K ) are membrane proteins that allow selective flow of K ions in a voltage-dependent manner. These channels play an important...
Voltage gated potassium channels (K V ) are membrane proteins that allow selective flow of K + ions in a voltage-dependent manner. These channels play an...
Voltage gated potassium channels (Kv) are membrane proteins that allow selective flow of K+ ions in a voltage-dependent manner. These channels play an...
SourceID doaj
pubmedcentral
proquest
crossref
pubmed
SourceType Open Website
Open Access Repository
Aggregation Database
Index Database
StartPage 578
SubjectTerms K2P
KATP
KCA
Kv7.1
Physiology
PUFAs
Shaker K channels
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Title In-Depth Study of the Interaction, Sensitivity, and Gating Modulation by PUFAs on K + Channels; Interaction and New Targets
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Volume 7
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