T-cell receptor ligation by peptide/MHC induces activation of a caspase in immature thymocytes: the molecular basis of negative selection

T‐cell receptors (TCRs) are created by a stochastic gene rearrangement process during thymocyte development, generating thymocytes bearing useful, as well as unwanted, specificities. Within the latter group, autoreactive thymocytes arise which are subsequently eliminated via a thymocyte‐specific apo...

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Bibliographic Details
Published in:	The EMBO Journal Vol. 16; no. 9; pp. 2282 - 2293
Main Authors:	Clayton, Linda K., Ghendler, Yoseph, Mizoguchi, Emiko, Patch, Raymond J., Ocain, Timothy D., Orth, Kim, Bhan, Atul K., Dixit, Vishva M., Reinherz, Ellis L.
Format:	Journal Article
Language:	English
Published:	Chichester, UK John Wiley & Sons, Ltd 01-05-1997
Subjects:	Amino Acid Chloromethyl Ketones - pharmacology Animals Antibodies, Monoclonal Apoptosis caspase Caspase 3 Caspase 6 Caspase 7 Caspases Cysteine Endopeptidases - metabolism Cysteine Proteinase Inhibitors - pharmacology Enzyme Activation Enzyme Precursors - metabolism Female Glucocorticoids - pharmacology Ligands Major Histocompatibility Complex Male Mice Mice, Inbred C57BL negative selection Peptides - metabolism Receptors, Antigen, T-Cell - immunology Receptors, Antigen, T-Cell - metabolism Signal Transduction T-Lymphocytes - cytology T-Lymphocytes - enzymology thymus Thymus Gland - cytology Thymus Gland - embryology Thymus Gland - enzymology
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