An investigation of candidate regions for association with bipolar disorder

We performed a case–control study of 1,000 cases and 1,028 controls on 1,509 markers, 1,139 of which were located in a 8 Mb region on chromosome 6 (105–113 Mb). This region has shown evidence of involvement in bipolar disorder (BP) in a number of other studies. We find association between BP and two...

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Published in:	American journal of medical genetics. Part B, Neuropsychiatric genetics Vol. 153B; no. 7; pp. 1292 - 1297
Main Authors:	Knight, Jo, Rochberg, Nanette S., Saccone, Scott F., Nurnberger Jr, John I., Rice, John P.
Format:	Journal Article
Language:	English
Published:	Hoboken Wiley Subscription Services, Inc., A Wiley Company 01-10-2010 Wiley-Liss
Subjects:	Adenosine Triphosphatases Adenosinetriphosphatase Adult and adolescent clinical studies association Biological and medical sciences Bipolar disorder Bipolar Disorder - enzymology Bipolar Disorder - genetics Bipolar disorders Case-Control Studies chromosome 6 Chromosomes, Human, Pair 6 Genetic Association Studies Genetic Markers genetics Genotype Humans Medical genetics Medical sciences Miscellaneous Mood disorders Polymorphism, Single Nucleotide Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Single-nucleotide polymorphism Mood disorder Genetics Bipolar disorder Association
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Abstract	We performed a case–control study of 1,000 cases and 1,028 controls on 1,509 markers, 1,139 of which were located in a 8 Mb region on chromosome 6 (105–113 Mb). This region has shown evidence of involvement in bipolar disorder (BP) in a number of other studies. We find association between BP and two SNPs in the gene LACE1. SNP rs9486880 and rs11153113 (both have P‐values of 2 × 10−5). Both P‐values are in the top 5% of the distribution derived from null simulations (P = 0.02 and 0.01, respectively). LACE is a good candidate for BP; it is an ATPase. We genotyped 173 other markers in 17 other positional and/or functional loci but found no further evidence of association with BP. © 2010 Wiley‐Liss, Inc.
AbstractList	We performed a case-control study of 1,000 cases and 1,028 controls on 1,509 markers, 1,139 of which were located in a 8 Mb region on chromosome 6 (105-113 Mb). This region has shown evidence of involvement in bipolar disorder (BP) in a number of other studies. We find association between BP and two SNPs in the gene LACE1. SNP rs9486880 and rs11153113 (both have P-values of 2 × 10(-5)). Both P-values are in the top 5% of the distribution derived from null simulations (P = 0.02 and 0.01, respectively). LACE is a good candidate for BP; it is an ATPase. We genotyped 173 other markers in 17 other positional and/or functional loci but found no further evidence of association with BP. Abstract We performed a case–control study of 1,000 cases and 1,028 controls on 1,509 markers, 1,139 of which were located in a 8 Mb region on chromosome 6 (105–113 Mb). This region has shown evidence of involvement in bipolar disorder (BP) in a number of other studies. We find association between BP and two SNPs in the gene LACE1. SNP rs9486880 and rs11153113 (both have P ‐values of 2 × 10 −5 ). Both P ‐values are in the top 5% of the distribution derived from null simulations ( P = 0.02 and 0.01, respectively). LACE is a good candidate for BP; it is an ATPase. We genotyped 173 other markers in 17 other positional and/or functional loci but found no further evidence of association with BP. © 2010 Wiley‐Liss, Inc. We performed a case-control study of 1,000 cases and 1,028 controls on 1,509 markers, 1,139 of which were located in a 8Mb region on chromosome 6 (105-113Mb). This region has shown evidence of involvement in bipolar disorder (BP) in a number of other studies. We find association between BP and two SNPs in the gene LACE1. SNP rs9486880 and rs11153113 (both have P-values of 2X10-5). Both P-values are in the top 5% of the distribution derived from null simulations (P=0.02 and 0.01, respectively). LACE is a good candidate for BP; it is an ATPase. We genotyped 173 other markers in 17 other positional and/or functional loci but found no further evidence of association with BP. copyright 2010 Wiley-Liss, Inc. We performed a case–control study of 1,000 cases and 1,028 controls on 1,509 markers, 1,139 of which were located in a 8 Mb region on chromosome 6 (105–113 Mb). This region has shown evidence of involvement in bipolar disorder (BP) in a number of other studies. We find association between BP and two SNPs in the gene LACE1. SNP rs9486880 and rs11153113 (both have P‐values of 2 × 10−5). Both P‐values are in the top 5% of the distribution derived from null simulations (P = 0.02 and 0.01, respectively). LACE is a good candidate for BP; it is an ATPase. We genotyped 173 other markers in 17 other positional and/or functional loci but found no further evidence of association with BP. © 2010 Wiley‐Liss, Inc. We performed a case control study of 1,000 cases and 1,028 controls on 1,509 markers, 1,139 of which were located in a 8 Mb region on chromosome 6 (105-113 Mb). This region has shown evidence of involvement in BP in a number of other studies. We find association between BP and two SNPs in the gene LACE1. SNP rs9486880 and rs11153113 (both have p-values of 2 × 10 -5 ). Both p-values are in the top 5% of the distribution derived from null simulations (p=0.02 and 0.01 respectively). LACE is a good candidate for BP; it is an ATPase. We genotyped 173 other markers in 17 other positional and/or functional loci but found no further evidence of association with BP.
Author	Rochberg, Nanette S. Nurnberger Jr, John I. Saccone, Scott F. Rice, John P. Knight, Jo
AuthorAffiliation	10 Unit on the Genetic Basis of Mood and Anxiety Disorders, Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, US Dept of Health & Human Services, Bethesda, MD, USA 11 Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IA, USA 5 Department of Psychiatry, University of California, Irvine 7 University of Pennsylvania, Philadelphia, PA, USA 2 National Institute for Health Research (NIHR), Biomedical Research Centre, Guy's and St. Thomas' NHS Foundation Trust and King's College London, London, UK 4 Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA 12 Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, USA 13 Department of Psychiatry, Howard University, Washington, D.C 3 Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA 9 Department of Psychiatry, Rush University Medical Center, Chicag
AuthorAffiliation_xml	– name: 9 Department of Psychiatry, Rush University Medical Center, Chicago, IL, USA – name: 8 Laboratory of Clinical Science, National Institute of Mental Health Intramural Research Program, National Institutes of Health, US Dept of Health & Human Services, Bethesda, MD, USA – name: 6 Department of Psychiatry, University of California, San Diego, CA, USA – name: 1 Department of Medical and Molecular Genetics, King's College London School of Medicine, Guy's Hospital, London, UK – name: 7 University of Pennsylvania, Philadelphia, PA, USA – name: 4 Department of Psychiatry and Behavioral Sciences, Johns Hopkins University School of Medicine, Baltimore, MD, USA – name: 5 Department of Psychiatry, University of California, Irvine – name: 3 Department of Psychiatry, Washington University School of Medicine, St. Louis, MO, USA – name: 12 Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN, USA – name: 11 Department of Psychiatry, University of Iowa Carver College of Medicine, Iowa City, IA, USA – name: 13 Department of Psychiatry, Howard University, Washington, D.C – name: 10 Unit on the Genetic Basis of Mood and Anxiety Disorders, Mood and Anxiety Disorders Program, National Institute of Mental Health, National Institutes of Health, US Dept of Health & Human Services, Bethesda, MD, USA – name: 2 National Institute for Health Research (NIHR), Biomedical Research Centre, Guy's and St. Thomas' NHS Foundation Trust and King's College London, London, UK
Author_xml	– sequence: 1 givenname: Jo surname: Knight fullname: Knight, Jo email: jo.knight@kcl.ac.uk organization: Department of Medical and Molecular Genetics, King's College London School of Medicine, Guy's Hospital, London, UK – sequence: 2 givenname: Nanette S. surname: Rochberg fullname: Rochberg, Nanette S. organization: Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri – sequence: 3 givenname: Scott F. surname: Saccone fullname: Saccone, Scott F. organization: Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri – sequence: 4 givenname: John I. surname: Nurnberger Jr fullname: Nurnberger Jr, John I. organization: Department of Psychiatry, Indiana University School of Medicine, Indianapolis, Indiana – sequence: 5 givenname: John P. surname: Rice fullname: Rice, John P. organization: Department of Psychiatry, Washington University School of Medicine, St. Louis, Missouri
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Copyright	Copyright © 2010 Wiley‐Liss, Inc. 2015 INIST-CNRS
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Notes	NIH - No. 5R01MH059534-08; No. U24 MH068457 istex:24A9B762682C00AD2A147CEA2CC57BD09D3C9A1A ArticleID:AJMG31100 ark:/67375/WNG-N354WB6R-L National Institute for Health Research (NIHR) National Institute of Mental Health How to cite this article: Knight J, Rochberg NS, Saccone SF, Nurnberger JI, NIMH Genetics Initiative Bipolar Disorder Consortium, Rice JP. 2010. An Investigation of Candidate Regions for Association With Bipolar Disorder. Am J Med Genet Part B 153B:1292-1297. How to cite this article: Knight J, Rochberg NS, Saccone SF, Nurnberger JI, NIMH Genetics Initiative Bipolar Disorder Consortium, Rice JP. 2010. An Investigation of Candidate Regions for Association With Bipolar Disorder. Am J Med Genet Part B 153B:1292–1297. ObjectType-Article-2 SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 23 ObjectType-Article-1 ObjectType-Feature-2
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Snippet	We performed a case–control study of 1,000 cases and 1,028 controls on 1,509 markers, 1,139 of which were located in a 8 Mb region on chromosome 6 (105–113... We performed a case-control study of 1,000 cases and 1,028 controls on 1,509 markers, 1,139 of which were located in a 8 Mb region on chromosome 6 (105-113... Abstract We performed a case–control study of 1,000 cases and 1,028 controls on 1,509 markers, 1,139 of which were located in a 8 Mb region on chromosome 6... We performed a case-control study of 1,000 cases and 1,028 controls on 1,509 markers, 1,139 of which were located in a 8Mb region on chromosome 6 (105-113Mb).... We performed a case control study of 1,000 cases and 1,028 controls on 1,509 markers, 1,139 of which were located in a 8 Mb region on chromosome 6 (105-113...
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SubjectTerms	Adenosine Triphosphatases Adenosinetriphosphatase Adult and adolescent clinical studies association Biological and medical sciences Bipolar disorder Bipolar Disorder - enzymology Bipolar Disorder - genetics Bipolar disorders Case-Control Studies chromosome 6 Chromosomes, Human, Pair 6 Genetic Association Studies Genetic Markers genetics Genotype Humans Medical genetics Medical sciences Miscellaneous Mood disorders Polymorphism, Single Nucleotide Psychology. Psychoanalysis. Psychiatry Psychopathology. Psychiatry Single-nucleotide polymorphism
Title	An investigation of candidate regions for association with bipolar disorder
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