An investigation of candidate regions for association with bipolar disorder

• Published in: American journal of medical genetics. Part B, Neuropsychiatric genetics Vol. 153B; no. 7; pp. 1292 - 1297
• Main Authors: Knight, Jo, Rochberg, Nanette S., Saccone, Scott F., Nurnberger Jr, John I., Rice, John P.
• Format: Journal Article
• Language: English
• Published: Hoboken Wiley Subscription Services, Inc., A Wiley Company 01-10-2010; Wiley-Liss
• Subjects: Adenosine Triphosphatases; Adenosinetriphosphatase; Adult and adolescent clinical studies; association; Biological and medical sciences; Bipolar disorder; Bipolar Disorder - enzymology; Bipolar Disorder - genetics; Bipolar disorders; Case-Control Studies; chromosome 6; Chromosomes, Human, Pair 6; Genetic Association Studies; Genetic Markers; genetics; Genotype; Humans; Medical genetics; Medical sciences; Miscellaneous; Mood disorders; Polymorphism, Single Nucleotide; Psychology. Psychoanalysis. Psychiatry; Psychopathology. Psychiatry; Single-nucleotide polymorphism; Mood disorder; Genetics; Bipolar disorder; Association
• ISSN: 1552-4841; 1552-485X; 1552-485X
• DOI: 10.1002/ajmg.b.31100

We performed a case–control study of 1,000 cases and 1,028 controls on 1,509 markers, 1,139 of which were located in a 8 Mb region on chromosome 6 (105–113 Mb). This region has shown evidence of involvement in bipolar disorder (BP) in a number of other studies. We find association between BP and two SNPs in the gene LACE1. SNP rs9486880 and rs11153113 (both have P‐values of 2 × 10−5). Both P‐values are in the top 5% of the distribution derived from null simulations (P = 0.02 and 0.01, respectively). LACE is a good candidate for BP; it is an ATPase. We genotyped 173 other markers in 17 other positional and/or functional loci but found no further evidence of association with BP. © 2010 Wiley‐Liss, Inc.