The GPI Anchor of Cell-Surface Proteins Is Synthesized on the Cytoplasmic Face of the Endoplasmic Reticulum

Glycosylphosphatidylinositol (GPI) membrane protein anchors are synthesized from sugar nucleotides and phospholipids in the ER and transferred to newly synthesized proteins destined for the cell surface. The topology of GPI synthesis in the ER was investigated using sealed trypanosome microsomes and...

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Bibliographic Details
Published in:	The Journal of cell biology Vol. 127; no. 2; pp. 333 - 341
Main Authors:	Vidugiriene, Jolanta, Menon, Anant K.
Format:	Journal Article
Language:	English
Published:	United States Rockefeller University Press 01-10-1994 The Rockefeller University Press
Subjects:	Animals Biosynthesis Cell membranes Cells Cellular biology Concanavalin A - metabolism Cytoplasm - metabolism Endopeptidase K Endoplasmic Reticulum - metabolism Glycosylphosphatidylinositols - biosynthesis Hydrolysis Ice Lipid Bilayers - metabolism Lipids Mannose - metabolism Mayors Membrane glycoproteins Membranes Microsomes Microsomes - metabolism Phosphatidylinositol Diacylglycerol-Lyase Phosphoinositide Phospholipase C Phosphoric Diester Hydrolases - metabolism Proteins Serine Endopeptidases - metabolism Trypanosoma Trypanosoma brucei brucei - metabolism Trypanosoma brucei brucei - ultrastructure Trypanosome Variant Surface Glycoproteins, Trypanosoma - metabolism
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