Specification of auditory sensitivity by Drosophila TRP channels

Ears achieve their exquisite sensitivity by means of mechanical feedback: motile mechanosensory cells through their active motion boost the mechanical input from the ear. Examination of the auditory mechanics in Drosophila melanogaster mutants shows that the transient receptor potential (TRP) channe...

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Bibliographic Details
Published in:	Nature neuroscience Vol. 9; no. 8; pp. 999 - 1000
Main Authors:	Göpfert, Martin C, Albert, Jörg T, Nadrowski, B, Kamikouchi, A
Format:	Journal Article
Language:	English
Published:	United States Nature Publishing Group 01-08-2006
Subjects:	Animals Auditory Perception - physiology Calcium Channels - genetics Calcium Channels - metabolism Drosophila Drosophila melanogaster Drosophila melanogaster - anatomy & histology Drosophila melanogaster - physiology Drosophila Proteins - genetics Drosophila Proteins - metabolism Ear ossicles Ears & hearing Hearing - physiology Insects Ion Channels - genetics Ion Channels - metabolism Neural transmission Regulation Sensory memory Sound Transient Receptor Potential Channels Velocity Germany Oregon United States > US
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Summary:	Ears achieve their exquisite sensitivity by means of mechanical feedback: motile mechanosensory cells through their active motion boost the mechanical input from the ear. Examination of the auditory mechanics in Drosophila melanogaster mutants shows that the transient receptor potential (TRP) channel NompC is required to promote this feedback, whereas the TRP vanilloid (TRPV) channels Nan and Iav serve to control the feedback gain. The combined function of these channels specifies the sensitivity of the fly auditory organ.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 ObjectType-Article-2 ObjectType-Feature-1
ISSN:	1097-6256 1546-1726
DOI:	10.1038/nn1735