The Hair Growth-Promoting Effect of Rumex japonicus Houtt. Extract

Rumex japonicus Houtt. is traditionally used as a medicinal plant to treat patients suffering from skin disease in Korea. However, the beneficial effect of Rumex japonicus Houtt. on hair growth has not been thoroughly examined. Therefore, the present study aims to investigate the hair growth-promoti...

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Published in:	Evidence-based complementary and alternative medicine Vol. 2016; no. 2016; pp. 1 - 10
Main Authors:	Noh, Byung Seung, Heo, Jeong-Doo, Kim, Euikyung, Kang, Changkeun, Byun, Jae Kuk, Kwon, Young Chul, Choudhary, Indu, Heo, Yunwi, Bae, Seong Kyeong, Yang, Hyeryeon, Kim, Na-Hyun, Lee, Hyunkyoung, Yim, Hyeong Jun
Format:	Journal Article
Language:	English
Published:	Cairo, Egypt Hindawi Publishing Corporation 01-01-2016 John Wiley & Sons, Inc Hindawi Limited
Subjects:	Analysis Growth Hair loss Immunohistochemistry Kinases Medical research Medicine, Botanic Medicine, Herbal Mice Proteins Skin Skin diseases Studies South Korea Japan United States > US
Online Access:	Get full text
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Abstract	Rumex japonicus Houtt. is traditionally used as a medicinal plant to treat patients suffering from skin disease in Korea. However, the beneficial effect of Rumex japonicus Houtt. on hair growth has not been thoroughly examined. Therefore, the present study aims to investigate the hair growth-promoting effect of Rumex japonicus (RJ) Houtt. root extract using human dermal papilla cells (DPCs), HaCaT cells, and C57BL/6 mice model. RJ induced antiapoptotic and proliferative effects on DPCs and HaCaT cells by increasing Bcl-2/Bax ratio and activating cellular proliferation-related proteins, ERK and Akt. RJ also increased β-catenin via the inhibition of GSK-3β. In C57BL/6 mice model, RJ promoted the anagen induction and maintained its period. Immunohistochemistry analysis demonstrated that RJ upregulated Ki-67 and β-catenin expressions, suggesting that the hair growth effect of RJ may be mediated through the reinforcement of hair cell proliferation. These results provided important insights for the possible mechanism of action of RJ and its potential as therapeutic agent to promote hair growth.
AbstractList	Rumex japonicus Houtt. is traditionally used as a medicinal plant to treat patients suffering from skin disease in Korea. However, the beneficial effect of Rumex japonicus Houtt. on hair growth has not been thoroughly examined. Therefore, the present study aims to investigate the hair growth-promoting effect of Rumex japonicus (RJ) Houtt. root extract using human dermal papilla cells (DPCs), HaCaT cells, and C57BL/6 mice model. RJ induced antiapoptotic and proliferative effects on DPCs and HaCaT cells by increasing Bcl-2/Bax ratio and activating cellular proliferation-related proteins, ERK and Akt. RJ also increased β-catenin via the inhibition of GSK-3β. In C57BL/6 mice model, RJ promoted the anagen induction and maintained its period. Immunohistochemistry analysis demonstrated that RJ upregulated Ki-67 and β-catenin expressions, suggesting that the hair growth effect of RJ may be mediated through the reinforcement of hair cell proliferation. These results provided important insights for the possible mechanism of action of RJ and its potential as therapeutic agent to promote hair growth. Rumex japonicus Houtt. is traditionally used as a medicinal plant to treat patients suffering from skin disease in Korea. However, the beneficial effect of Rumex japonicus Houtt. on hair growth has not been thoroughly examined. Therefore, the present study aims to investigate the hair growth-promoting effect of Rumex japonicus (RJ) Houtt. root extract using human dermal papilla cells (DPCs), HaCaT cells, and C57BL/6 mice model. RJ induced antiapoptotic and proliferative effects on DPCs and HaCaT cells by increasing Bcl-2/Bax ratio and activating cellular proliferation-related proteins, ERK and Akt. RJ also increased β -catenin via the inhibition of GSK-3 β . In C57BL/6 mice model, RJ promoted the anagen induction and maintained its period. Immunohistochemistry analysis demonstrated that RJ upregulated Ki-67 and β -catenin expressions, suggesting that the hair growth effect of RJ may be mediated through the reinforcement of hair cell proliferation. These results provided important insights for the possible mechanism of action of RJ and its potential as therapeutic agent to promote hair growth. Rumex japonicus Houtt. is traditionally used as a medicinal plant to treat patients suffering from skin disease in Korea. However, the beneficial effect of Rumex japonicus Houtt. on hair growth has not been thoroughly examined. Therefore, the present study aims to investigate the hair growth‐promoting effect of Rumex japonicus (RJ) Houtt. root extract using human dermal papilla cells (DPCs), HaCaT cells, and C57BL/6 mice model. RJ induced antiapoptotic and proliferative effects on DPCs and HaCaT cells by increasing Bcl‐2/Bax ratio and activating cellular proliferation‐related proteins, ERK and Akt. RJ also increased β ‐catenin via the inhibition of GSK‐3 β . In C57BL/6 mice model, RJ promoted the anagen induction and maintained its period. Immunohistochemistry analysis demonstrated that RJ upregulated Ki‐67 and β ‐catenin expressions, suggesting that the hair growth effect of RJ may be mediated through the reinforcement of hair cell proliferation. These results provided important insights for the possible mechanism of action of RJ and its potential as therapeutic agent to promote hair growth. Houtt. is traditionally used as a medicinal plant to treat patients suffering from skin disease in Korea. However, the beneficial effect of Houtt. on hair growth has not been thoroughly examined. Therefore, the present study aims to investigate the hair growth-promoting effect of (RJ) Houtt. root extract using human dermal papilla cells (DPCs), HaCaT cells, and C57BL/6 mice model. RJ induced antiapoptotic and proliferative effects on DPCs and HaCaT cells by increasing Bcl-2/Bax ratio and activating cellular proliferation-related proteins, ERK and Akt. RJ also increased -catenin via the inhibition of GSK-3 . In C57BL/6 mice model, RJ promoted the anagen induction and maintained its period. Immunohistochemistry analysis demonstrated that RJ upregulated Ki-67 and -catenin expressions, suggesting that the hair growth effect of RJ may be mediated through the reinforcement of hair cell proliferation. These results provided important insights for the possible mechanism of action of RJ and its potential as therapeutic agent to promote hair growth.
Audience	Academic
Author	Heo, Jeong-Doo Kang, Changkeun Kwon, Young Chul Noh, Byung Seung Byun, Jae Kuk Lee, Hyunkyoung Kim, Euikyung Heo, Yunwi Yim, Hyeong Jun Kim, Na-Hyun Choudhary, Indu Yang, Hyeryeon Bae, Seong Kyeong
AuthorAffiliation	4 Institutes of Agriculture and Life Science, Gyeongsang National University, Jinju 52828, Republic of Korea 5 Biobeauty Korea Co., Ltd., Kyungsung University Business Incubator, Busan 48434, Republic of Korea 2 Institute of Animal Medicine, Gyeongsang National University, Jinju 52828, Republic of Korea 3 Gyeongnam Department of Environment Toxicology and Chemistry, Toxicity Screening Research Center, Korea Institute of Toxicology, Jinju 52834, Republic of Korea 1 College of Veterinary Medicine, Gyeongsang National University, Jinju 52828, Republic of Korea
AuthorAffiliation_xml	– name: 4 Institutes of Agriculture and Life Science, Gyeongsang National University, Jinju 52828, Republic of Korea – name: 3 Gyeongnam Department of Environment Toxicology and Chemistry, Toxicity Screening Research Center, Korea Institute of Toxicology, Jinju 52834, Republic of Korea – name: 2 Institute of Animal Medicine, Gyeongsang National University, Jinju 52828, Republic of Korea – name: 5 Biobeauty Korea Co., Ltd., Kyungsung University Business Incubator, Busan 48434, Republic of Korea – name: 1 College of Veterinary Medicine, Gyeongsang National University, Jinju 52828, Republic of Korea
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ContentType	Journal Article
Copyright	Copyright © 2016 Hyunkyoung Lee et al. COPYRIGHT 2016 John Wiley & Sons, Inc. Copyright © 2016 Hyunkyoung Lee et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Copyright © 2016 Hyunkyoung Lee et al. 2016
Copyright_xml	– notice: Copyright © 2016 Hyunkyoung Lee et al. – notice: COPYRIGHT 2016 John Wiley & Sons, Inc. – notice: Copyright © 2016 Hyunkyoung Lee et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. – notice: Copyright © 2016 Hyunkyoung Lee et al. 2016
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Snippet	Rumex japonicus Houtt. is traditionally used as a medicinal plant to treat patients suffering from skin disease in Korea. However, the beneficial effect of... Houtt. is traditionally used as a medicinal plant to treat patients suffering from skin disease in Korea. However, the beneficial effect of Houtt. on hair... Rumex japonicus Houtt. is traditionally used as a medicinal plant to treat patients suffering from skin disease in Korea. However, the beneficial effect of...
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SubjectTerms	Analysis Growth Hair loss Immunohistochemistry Kinases Medical research Medicine, Botanic Medicine, Herbal Mice Proteins Skin Skin diseases Studies
Title	The Hair Growth-Promoting Effect of Rumex japonicus Houtt. Extract
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