Serum Parathyroid Hormone Is a New Potential Risk Factor in Multiple Myeloma

• Published in: BioMed research international Vol. 2014; no. 2014; pp. 1 - 7
• Main Authors: Kang, Min-Gu, Won, Eun-Jeong, Choi, Hyun-Woo, Kim, Hye-Ran, Choi, Hyun-Jung, Park, Hye-Ri, Shin, Jong-Hee, Suh, Soon-Pal, Ryang, Dong-Wook, Shin, Myung-Geun
• Format: Journal Article
• Language: English
• Published: Cairo, Egypt Hindawi Puplishing Corporation 01-01-2014; Hindawi Publishing Corporation; John Wiley & Sons, Inc; Hindawi Limited
• Subjects: Adult; Aged; Biomarkers, Tumor - blood; Bone marrow; Chromosomes; Dehydrogenases; Disease-Free Survival; Female; Health aspects; Hormones; Humans; Male; Medical prognosis; Multiple myeloma; Multiple Myeloma - blood; Multiple Myeloma - diagnosis; Multiple Myeloma - mortality; Parathyroid hormone; Parathyroid Hormone - blood; Physiological aspects; Plasma; Proteins; Risk Factors; Survival Rate; United States; South Korea
• ISSN: 2314-6133; 2314-6141
• DOI: 10.1155/2014/804182

We hypothesized that serum PTH might be associated with various clinicopathological parameters in multiple myeloma (MM). So we investigated the implications of serum PTH in MM patients and the relationship with other risk factors of MM. A total of 115 patients who were newly diagnosed with MM were enrolled. Serum PTH level was 24.7 ± 34.9 (ranged 0.0–284.1) pg/mL. Serum levels of IgG, IgM, FLC-lambda, albumin, and LDH were in positive correlation with serum PTH. Compared to non-high PTH (<68.3 pg/mL) group, the hazard ratio (HR) for overall survival was higher for group with high PTH level (≥68.3 pg/mL) (HR, 1.710). Furthermore, the patient group with high PTH level showed inferior progression-free survival than non-high PTH group (P=0.056). Interestingly, subgroup analysis showed that serum PTH level at diagnosis was associated with risk factors and clinical outcome in MM patients, especially in complete remission group, transplantation cases, ISS stage II cases, and cases without chromosome abnormality. In conclusion, this study showed that blood PTH level in MM at diagnosis was associated with risk factors and clinical outcome in MM patients.