Antimicrobial Resistance in Enterobacterales Recovered from Urinary Tract Infections in France

• Published in: Pathogens (Basel) Vol. 11; no. 3; p. 356
• Main Authors: Farfour, Eric, Dortet, Laurent, Guillard, Thomas, Chatelain, Nicolas, Poisson, Agathe, Mizrahi, Assaf, Fournier, Damien, Bonnin, Rémy A, Degand, Nicolas, Morand, Philippe, Janvier, Frédéric, Fihman, Vincent, Corvec, Stéphane, Broutin, Lauranne, Le Brun, Cécile, Yin, Nicolas, Héry-Arnaud, Geneviève, Grillon, Antoine, Bille, Emmanuelle, Jean-Pierre, Hélène, Amara, Marlène, Jaureguy, Francoise, Isnard, Christophe, Cattoir, Vincent, Diedrich, Tristan, Flevin, Emilie, Merens, Audrey, Jacquier, Hervé, Vasse, Marc, On Behalf Of The Gmc Study Group
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 15-03-2022; MDPI
• Subjects: Amdinocillin; Antibiotics; Antimicrobial agents; Antimicrobial resistance; carbapenem; Cefoxitin; Ciprofloxacin; Cotrimoxazole; Drug resistance; E coli; Enterobacter cloacae; Enterobacterales; ESBL; Fosfomycin; Gynecology; Hematology; Intensive care; Klebsiella; Klebsiella pneumoniae; Life Sciences; Long-term care; Nitrofurantoin; Obstetrics; Pediatrics; Pivmecillinam; Temocillin; Urinary tract; Urinary tract diseases; urinary tract infection (UTI); Urinary tract infections; Urogenital system; France; urinary tract infection (UTI); Enterobacterales; carbapenem; ESBL; temocillin; pivmecillinam; fosfomycin; nitrofurantoin
• ISSN: 2076-0817; 2076-0817
• DOI: 10.3390/pathogens11030356

In the context of increasing antimicrobial resistance in Enterobacterales, the management of these UTIs has become challenging. We retrospectively assess the prevalence of antimicrobial resistance in Enterobacterales isolates recovered from urinary tract samples in France, between 1 September 2017, to 31 August 2018. Twenty-six French clinical laboratories provided the susceptibility of 134,162 Enterobacterales isolates to 17 antimicrobials. The most frequent species were
(72.0%),
(9.7%),
(5.8%), and
complex (2.9%). The overall rate of ESBL-producing Enterobacterales was 6.7%, and ranged from 1.0% in
to 19.5% in
, and from 3.1% in outpatients to 13.6% in long-term care facilities. Overall, 4.1%, 9.3% and 10.5% of the isolates were resistant to cefoxitin, temocillin and pivmecillinam. Cotrimoxazole was the less active compound with 23.4% resistance. Conversely, 4.4%, 12.9%, and 14.3% of the strains were resistant to fosfomycin, nitrofurantoin, and ciprofloxacin. However, less than 1% of
was resistant to fosfomycin and nitrofurantoin. We identified several trends in antibiotics resistances among Enterobacterales isolates recovered from the urinary tract samples in France. Carbapenem-sparing drugs, such as temocillin, mecillinam, fosfomycin, cefoxitin, and nitrofurantoin, remained highly active, including towards ESBL-E.