Primary Biliary Cirrhosis Associated with Multiple Myeloma

• Published in: Internal Medicine Vol. 32; no. 10; pp. 802 - 805
• Main Authors: KANEKO, Haruo, ENDO, Takao, SAITOH, Hirokazu, KATSUTA, Yasumi, ARAMAKI, Takumi, HAYAKAWA, Hirokazu
• Format: Journal Article
• Language: English
• Published: Tokyo The Japanese Society of Internal Medicine 1993; Japanese Society of Internal Medicine
• Subjects: Aged; autoimmune disease; Biological and medical sciences; Gastroenterology. Liver. Pancreas. Abdomen; Humans; Immunoglobulin A - blood; Immunoglobulin kappa-Chains - blood; Liver Cirrhosis, Biliary - complications; Liver Cirrhosis, Biliary - immunology; Liver. Biliary tract. Portal circulation. Exocrine pancreas; Male; malignancy; Medical sciences; monoclonal gammopathy; Multiple Myeloma - complications; Multiple Myeloma - immunology; Multiple Myeloma - pathology; Other diseases. Semiology; Paraproteinemias - complications; Paraproteinemias - immunology; Case study; Human; Biliary tract; Immunopathology; Concomitant disease; Primary; Digestive diseases; Autoimmune disease; Malignant hemopathy; Biliary cirrhosis; Myeloma
• ISSN: 0918-2918; 1349-7235
• DOI: 10.2169/internalmedicine.32.802

An association between autoimmune disease and malignancy, in particular lymphoproliferative neoplasms, has been reported, as has an increased incidence of extrahepatic malignancy in primary biliary cirrhosis (PBC). Monoclonal immunoglobulin elevations in PBC are rare, and there have been only three cases in the literature of PBC associated with multiple myeloma. We describe a patient who was concurrently diagnosed as having PBC and multiple myeloma, and emphasize the need to consider myeloma when evaluating monoclonal gammopathy in PBC. We also discuss the possible mechanisms for the association of the two conditions. (Internal Medicine 32: 802-805, 1993)