The effect of surface coverage and conformation of poly(ethylene oxide) (PEO) chains of poloxamer 407 on the biological fate of model colloidal drug carriers

Poloxamer 407 was adsorbed onto the surface of model colloidal drug carriers, polystyrene nanoparticles of 40, 70 and 137 nm in diameter, and the effect of the degree of surface coverage and the conformation of the poly(ethylene oxide) (PEO) chains on biological fate was studied. The relationship be...

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Bibliographic Details
Published in:	Biochimica et biophysica acta Vol. 1514; no. 2; pp. 261 - 279
Main Authors:	Stolnik, S, Daudali, B, Arien, A, Whetstone, J, Heald, C.R, Garnett, M.C, Davis, S.S, Illum, L
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01-10-2001
Subjects:	Adsorption Animals Biodegradation, Environmental Biodistribution Blood Proteins - chemistry Colloids Computer Simulation Drug Carriers In Vitro Techniques Microspheres Molecular Conformation Nanoparticle Particle Size Poloxamer - chemistry Poloxamer - pharmacokinetics Poloxamer 407 Poly(ethylene oxide) Polyethylene Glycols - chemistry Polystyrenes Propylene Glycols - chemistry Rats Surface density Surface Properties Surface-Active Agents - chemistry Surface-Active Agents - pharmacokinetics Tissue Distribution Poloxamer 407 Poly(ethylene oxide) Surface density Nanoparticle Biodistribution
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