Perturbation of cellular mechanistic system by silver nanoparticle toxicity: Cytotoxic, genotoxic and epigenetic potentials

• Published in: Advances in colloid and interface science Vol. 221; pp. 4 - 21
• Main Authors: Dubey, Poornima, Matai, Ishita, Kumar, S. Uday, Sachdev, Abhay, Bhushan, Bharat, Gopinath, P.
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier B.V 01-07-2015
• Subjects: Apoptosis - drug effects; Apoptosis - physiology; Cell Physiological Phenomena - drug effects; Cytotoxicity; DNA Damage - physiology; Epigenesis, Genetic - drug effects; Epigenesis, Genetic - physiology; Epigenetic; Metal Nanoparticles - toxicity; Models, Biological; Molecular mechanisms; Nanotoxicology; Oxidative Stress - drug effects; Oxidative Stress - physiology; Protein corona; Reactive Oxygen Species - metabolism; Silver - toxicity; Silver nanoparticles; Cytotoxicity; Epigenetic; Nanotoxicology; Protein corona; Silver nanoparticles; Molecular mechanisms
• ISSN: 0001-8686; 1873-3727
• DOI: 10.1016/j.cis.2015.02.007

Currently the applications of silver nanoparticles (Ag NPs) are gaining overwhelming response due to the advancement of nanotechnology. However, only limited information is available with regard to their toxicity mechanism in different species. It is very essential to understand the complete molecular mechanism to explore the functional and long term applications of Ag NPs. Ag NPs could be toxic at cellular, subcellular, biomolecular, and epigenetic levels. Toxicity effects induced by Ag NPs have been evaluated using numerous in vitro and in vivo models, but still there are contradictions in interpretations due to disparity in methodology, test endpoints and several other model parameters which needs to be considered. Thus, this review article focuses on the progressive elucidation of molecular mechanism of toxicity induced by Ag NPs in various in vitro and in vivo models. Apart from these, this review also highlights the various ignored factors which are to be considered during toxicity studies.
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•Provides insight into cytotoxic, genotoxic and epigenetic potentials of Ag NPs•Progressive elucidation of molecular mechanisms of Ag NP toxicity in various models•Molecular determinants and signaling factors involved in Ag NP mediated toxicity•Highlighted the critical ignored factors for proper elucidation of molecular mechanisms•Revealed the possible interaction of Ag NPs with environment and their fate