Deciphering the combinatorial roles of geometric, mechanical, and adhesion cues in regulation of cell spreading

Significant effort has gone towards parsing out the effects of surrounding microenvironment on macroscopic behavior of stem cells. Many of the microenvironmental cues, however, are intertwined, and thus, further studies are warranted to identify the intricate interplay among the conflicting downstre...

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Bibliographic Details
Published in:	PloS one Vol. 8; no. 11; p. e81113
Main Authors:	Harris, Greg M, Shazly, Tarek, Jabbarzadeh, Ehsan
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 25-11-2013 Public Library of Science (PLoS)
Subjects:	Biomedical engineering Biomedical materials Cell Adhesion Cell adhesion & migration Cell Movement Cell spreading Cells, Cultured Chemical engineering Combinatorial analysis Cues Decoupling Elasticity Extracellular Matrix Finite Element Analysis Finite element method Fluorescent Antibody Technique Humans Hydrogels Interfaces Islands Ligands Mesenchymal Stem Cells - cytology Mesenchymal Stem Cells - enzymology Mesenchyme Microenvironments Motility Nanotechnology Pattern formation Physical characteristics Physical properties Polyethylene glycol Proteins Regenerative medicine rho-Associated Kinases - antagonists & inhibitors RhoA protein Signal transduction Signaling Spreading Stem cells Studies Substrates Tissue engineering Topography United States > US South Carolina
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