Hydrogen sulfide protects cardiomyocytes from doxorubicin-induced ferroptosis through the SLC7A11/GSH/GPx4 pathway by Keap1 S-sulfhydration and Nrf2 activation

Recent studies have demonstrated that ferroptosis, a novel form of nonapoptotic regulated cell death plays an important role in doxorubicin (DOX)-induced cardiotoxicity (DoIC). Hydrogen sulfide (H2S) is emerging as the third important gaseous mediator in cardiovascular system. However, whether H2S h...

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Bibliographic Details

Published in:	Redox biology Vol. 70; p. 103066
Main Authors:	Zhang, Hui, Pan, Jianan, Huang, Shuying, Chen, Xiaonan, Chang, Alex Chia Yu, Wang, Changqian, Zhang, Junfeng, Zhang, Huili
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01-04-2024 Elsevier
Subjects:	Doxorubicin-induced cardiotoxicity Ferroptosis Hydrogen sulfide Research Paper S-sulfhydrated Keap1 SLC7A11 Hydrogen sulfide Ferroptosis Doxorubicin-induced cardiotoxicity SLC7A11 S-sulfhydrated Keap1
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