Increased presence of FOXP3+ regulatory T cells in inflamed muscle of patients with active juvenile dermatomyositis compared to peripheral blood

Juvenile dermatomyositis (JDM) is an immune-mediated inflammatory disease affecting the microvasculature of skin and muscle. CD4+ CD25+ FOXP3+ regulatory T cells (Tregs) are key regulators of immune homeostasis. A role for Tregs in JDM pathogenesis has not yet been established. Here, we explored Tre...

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Bibliographic Details
Published in:	PloS one Vol. 9; no. 8; p. e105353
Main Authors:	Vercoulen, Yvonne, Bellutti Enders, Felicitas, Meerding, Jenny, Plantinga, Maud, Elst, Elisabeth F, Varsani, Hemlata, van Schieveen, Christa, Bakker, Mette H, Klein, Mark, Scholman, Rianne C, Spliet, Wim, Ricotti, Valeria, Koenen, Hans J P M, de Weger, Roel A, Wedderburn, Lucy R, van Royen-Kerkhof, Annet, Prakken, Berent J
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 26-08-2014 Public Library of Science (PLoS)
Subjects:	Adolescent Arthritis Biology and Life Sciences Biopsy Blood CD25 antigen CD4 antigen Cell activation Child Child, Preschool Children & youth Childrens health Cytokines Cytometry Dermatomyositis Dermatomyositis - blood Dermatomyositis - immunology Dermatomyositis - pathology Disease Disease control Dystrophy Female Flow cytometry Forkhead Transcription Factors - analysis Forkhead Transcription Factors - immunology Foxp3 protein Homeostasis Hospitals Humans Immunohistochemistry Immunology Immunoregulation Infant Infiltration Laboratories Lymphocytes Lymphocytes T Male Medicine and Health Sciences Microvasculature Muscles Muscles - immunology Muscles - pathology Muscular dystrophy Pathogenesis Patients Pediatrics Peripheral blood Phenotypes Regulators Remission Rheumatology T-Lymphocytes, Regulatory - immunology T-Lymphocytes, Regulatory - pathology San Francisco California Netherlands United Kingdom > UK United States > US Ireland
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