Identifying treatment options for BRAFV600 wild-type metastatic melanoma: A SU2C/MRA genomics-enabled clinical trial

Although combination BRAF and MEK inhibitors are highly effective for the 40-50% of cutaneous metastatic melanomas harboring BRAFV600 mutations, targeted agents have been ineffective for BRAFV600wild-type (wt) metastatic melanomas. The SU2C Genomics-Enabled Medicine for Melanoma Trial utilized a Sim...

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Bibliographic Details
Published in:	PloS one Vol. 16; no. 4; p. e0248097
Main Authors:	LoRusso, Patricia M, Sekulic, Aleksandar, Sosman, Jeffrey A, Liang, Winnie S, Carpten, John, Craig, David W, Solit, David B, Bryce, Alan H, Kiefer, Jeffrey A, Aldrich, Jessica, Nasser, Sara, Halperin, Rebecca, Byron, Sara A, Pilat, Mary Jo, Boerner, Scott A, Durecki, Diane, Hendricks, William P D, Enriquez, Daniel, Izatt, Tyler, Keats, Jonathan, Legendre, Christophe, Markovic, Svetomir N, Weise, Amy, Naveed, Fatima, Schmidt, Jessica, Basu, Gargi D, Sekar, Shobana, Adkins, Jonathan, Tassone, Erica, Sivaprakasam, Karthigayini, Zismann, Victoria, Calvert, Valerie S, Petricoin, Emanuel F, Fecher, Leslie Anne, Lao, Christopher, Eder, J Paul, Vogelzang, Nicholas J, Perlmutter, Jane, Gorman, Mark, Manica, Barbara, Fox, Lisa, Schork, Nicholas, Zelterman, Daniel, DeVeaux, Michelle, Joseph, Richard W, Cowey, C Lance, Trent, Jeffrey M
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 07-04-2021 Public Library of Science (PLoS)
Subjects:	Adult Aged Benzimidazoles - administration & dosage Biology and Life Sciences Cancer Cancer therapies Clinical trials Computer programs Damage Data analysis Editing Female Funding Genomics Health care facilities Health services Humans Immune checkpoint Immunology Immunotherapy Interrogation Male Medical prognosis Medical research Medicine Medicine and Health Sciences Melanoma Melanoma - drug therapy Melanoma - genetics Melanoma - metabolism Melanoma, Cutaneous Malignant Metastases Metastasis Methodology Middle Aged Mucosa Mutation Neoplasm Metastasis Patients Pilot Projects Prospective Studies Proteomics Proto-Oncogene Proteins B-raf - genetics Proto-Oncogene Proteins B-raf - metabolism Skin Skin Neoplasms - drug therapy Skin Neoplasms - genetics Skin Neoplasms - metabolism Software Survival Therapy Translation Tumors Visualization Los Angeles California Ann Arbor Michigan United States > US Detroit Michigan
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