The role of air pollution in myocardial remodeling

• Published in: PloS one Vol. 12; no. 4; p. e0176084
• Main Authors: de Oliveira-Fonoff, A M, Mady, C, Pessoa, F G, Fonseca, K C B, Salemi, V M C, Fernandes, F, Saldiva, P H N, Ramires, F J A
• Format: Journal Article
• Language: English
• Published: United States Public Library of Science 20-04-2017; Public Library of Science (PLoS)
• Subjects: Air Pollution; Animals; Apoptosis; Atmospheric pollution; Biology and Life Sciences; Cardiomyocytes; Cardiomyopathy; Collagen; Cytokines; Deposition; Engineering and Technology; Environmental impact; Exposure; Fibrosis; Gene expression; Glutathione; Heart; Heart attacks; Infarction; Inflammation; Inflammatory response; Laboratory animals; Male; Medicine and Health Sciences; Morbidity; Myocardial infarction; Myocardium; Outdoor air quality; Oxidative Stress; Particulate matter; Pollution; Rats; Rats, Wistar; Real-Time Polymerase Chain Reaction; Remodeling; Rodents; Stress analysis; Structure-function relationships; Tumor necrosis factor-α; Urban areas; Urban environments; Ventricle; Ventricular Remodeling; Brazil
• ISSN: 1932-6203; 1932-6203
• DOI: 10.1371/journal.pone.0176084

Excessive air pollution in urban environments can impact morbidity and mortality. The authors evaluated the role of particulate matter2.5 (PM2.5) in structural, geometric, and functional remodeling in hearts, using an experimental model of myocardial infarction.
Seventy-five rats were divided into 5 groups: control (CG), CG exposed to PM2.5 pollution (CGP), myocardial infarcted group (MI), infarcted group immediately exposed to pollution (IGP-I), and infarcted group previously exposed to pollution and kept exposed after infarction (IGP-II). Greater deposition of interstitial collagen occurred in the left ventricle in CGP, MI, IGP-I, and IGP-II groups compared with that in controls (p = 0.002 CG vs CGP and p<0.0001 CG vs MI, IGP-I, and IGP-II). In the right ventricle, greater collagen deposition existed in CGP, MI, IGP-I, and IGP-II compared with that in CG (p<0.021 CG vs CGP and p<0.0001 CG vs MI, IGP-I, and IGP-II). At the end of the study, CG had a higher mean shortening fraction than the other groups had (p≤0.03). Left ventricular systolic diameter was lower in CG than in infarcted groups (p≤0.003). The infarcted groups had greater expression of TGF-β (p≤0.04). PM2.5 increased the expression of TGF-β in the IGP-II compared with the MI group (p = 0.004). The TNF-α gene was overexpressed in the IGP-II compared with the CGP group (p = 0.012). INF-γ gene expression was greater in IGP-II (p≤0.01). Oxidative stress analysis showed a higher glutathione concentration in CGP (p = 0.03), MI (p = 0.014), and IGP-I (p = 0.008) compared with that in CG.
PM2.5 stimulates the deposition of fibrosis in the myocardium of healthy hearts, but not in infarcted hearts. PM2.5 modulates the inflammatory response, which was greater in the IGP-II group. It also modulates oxidative stress in healthy hearts but not in infarcted hearts.