The PPARγ locus makes long-range chromatin interactions with selected tissue-specific gene loci during adipocyte differentiation in a protein kinase A dependent manner

Differentiation signaling results in reprogramming of cellular gene expression that leads to morphological changes and functional specialization of a precursor cell. This global change in gene expression involves temporal regulation of differentiation-specific genes that are located throughout the g...

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Bibliographic Details
Published in:	PloS one Vol. 9; no. 1; p. e86140
Main Authors:	LeBlanc, Scott E, Wu, Qiong, Barutcu, A Rasim, Xiao, Hengyi, Ohkawa, Yasuyuki, Imbalzano, Anthony N
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 2014 Public Library of Science (PLoS)
Subjects:	3T3-L1 Cells Adipocytes Adipogenesis Adipokines - genetics Animals Biology Carrier Proteins - genetics CCAAT-Enhancer-Binding Protein-beta - metabolism Cell differentiation Chromatin Chromatin - metabolism Chromosomes Cyclic AMP Cyclic AMP-Dependent Protein Kinases - metabolism Developmental biology Differentiation (biology) Elongation Gene expression Gene Expression Regulation, Developmental Gene loci Gene regulation Genes Genetic Loci Genomes Genomics Kinases Laboratories Medical schools Mice Nuclei Nuclei (cytology) Perilipin-1 Phosphoproteins - genetics PPAR gamma - genetics Promoter Regions, Genetic Protein kinase A Proteins Proximity Signal Transduction Signaling Specialization Transcription activation Translation elongation United States > US Massachusetts
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