Expression profile of LncRNA ANRIL, miR-186, miR-181a, and MTMR-3 in patients with preeclampsia

Preeclampsia (PE) is a leading cause of maternal and neonatal morbidity and mortality worldwide. Several studies demonstrated the role of lncRNAs and miRNAs in the pathogenesis of preeclampsia; the aim was to detect the expression profiles of serum LncRNA ANRIL, miR-186, miR-181a, and MTMR-3 in pati...

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Published in:	Non-coding RNA research Vol. 8; no. 4; pp. 481 - 486
Main Authors:	Ayoub, Shymaa E., Shaker, Olfat G., Aboshama, Rehab Abdelhamid, Etman, Mohamed K., Khalefa, Abeer A., khamiss Abd elguaad, Mohamed M., Zaki, Othman M., Ali, Doaa Y., Hemeda, Nada F., Amin, Amal, Ali, Marwa A.
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier B.V 01-12-2023 KeAi Publishing KeAi Communications Co., Ltd
Subjects:	LncRNA ANRIL miR-181a miR-186 MTMR-3 Original Preeclampsia miR-181a MTMR-3 LncRNA ANRIL miR-186 Preeclampsia
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Abstract	Preeclampsia (PE) is a leading cause of maternal and neonatal morbidity and mortality worldwide. Several studies demonstrated the role of lncRNAs and miRNAs in the pathogenesis of preeclampsia; the aim was to detect the expression profiles of serum LncRNA ANRIL, miR-186, miR-181a, and MTMR-3 in patients with preeclampsia. The study included 160 subjects divided into 80 subjects considered as a control group, 80 patients with preeclampsia. We found that there was a significant difference between the preeclampsia and control groups with up-regulation of miR-186 median (IQR) = 4, 29 (1.35–7.73) (P < 0.0001), miR-181a median (IQR) = 2.45 (0.83–6.52) (P = 0.028), and downregulation of lncRNA ANRIL median (IQR) = 0.35(0.28–0.528) (P < 0.0001), MTMR median (IQR) = 0.32(0.155–1.11), (P < 0.0001). ROC curve of lncRNA ANRIL, miR-186, miR-181a, and MTMR-3 in preeclampsia patients showing the roles of these markers in the diagnosis of preeclampsia. In conclusion, serum LncRNA ANRIL, miR-186, miR-181a, and MTMR-3 could be promising biomarkers in the diagnosis of preeclampsia.
AbstractList	Preeclampsia (PE) is a leading cause of maternal and neonatal morbidity and mortality worldwide. Several studies demonstrated the role of lncRNAs and miRNAs in the pathogenesis of preeclampsia; the aim was to detect the expression profiles of serum LncRNA ANRIL, miR-186, miR-181a, and MTMR-3 in patients with preeclampsia. The study included 160 subjects divided into 80 subjects considered as a control group, 80 patients with preeclampsia. We found that there was a significant difference between the preeclampsia and control groups with up-regulation of miR-186 median (IQR) = 4, 29 (1.35–7.73) (P < 0.0001), miR-181a median (IQR) = 2.45 (0.83–6.52) (P = 0.028), and downregulation of lncRNA ANRIL median (IQR) = 0.35(0.28–0.528) (P < 0.0001), MTMR median (IQR) = 0.32(0.155–1.11), (P < 0.0001). ROC curve of lncRNA ANRIL, miR-186, miR-181a, and MTMR-3 in preeclampsia patients showing the roles of these markers in the diagnosis of preeclampsia. In conclusion, serum LncRNA ANRIL, miR-186, miR-181a, and MTMR-3 could be promising biomarkers in the diagnosis of preeclampsia.
Author	Aboshama, Rehab Abdelhamid Hemeda, Nada F. Ayoub, Shymaa E. khamiss Abd elguaad, Mohamed M. Zaki, Othman M. Shaker, Olfat G. Amin, Amal Etman, Mohamed K. Ali, Doaa Y. Khalefa, Abeer A. Ali, Marwa A.
Author_xml	– sequence: 1 givenname: Shymaa E. orcidid: 0000-0003-1688-3891 surname: Ayoub fullname: Ayoub, Shymaa E. email: ssa05@fayoum.edu.eg organization: Department of Biochemistry and Molecular Biology, Faculty of Medicine, Fayoum University, Al Fayoum, Egypt – sequence: 2 givenname: Olfat G. surname: Shaker fullname: Shaker, Olfat G. organization: Department of Biochemistry and Molecular Biology, Faculty of Medicine, Cairo University, Cairo, Egypt – sequence: 3 givenname: Rehab Abdelhamid surname: Aboshama fullname: Aboshama, Rehab Abdelhamid organization: Department of Obstetrics and Gynecology, Faculty of Medicine, Fayoum University, Al Fayoum, Egypt – sequence: 4 givenname: Mohamed K. surname: Etman fullname: Etman, Mohamed K. organization: Department of Obstetrics and Gynecology, Faculty of Medicine, Fayoum University, Al Fayoum, Egypt – sequence: 5 givenname: Abeer A. surname: Khalefa fullname: Khalefa, Abeer A. organization: Department of Physiology, Faculty of Medicine, Zagazig University, El Zagazig, Egypt – sequence: 6 givenname: Mohamed M. surname: khamiss Abd elguaad fullname: khamiss Abd elguaad, Mohamed M. organization: Department of Physiology, Faculty of Medicine, Fayoum University, Al Fayoum, Egypt – sequence: 7 givenname: Othman M. surname: Zaki fullname: Zaki, Othman M. organization: Department of Clinical Pathology, Faculty of Medicine, Damietta University, Damietta, Egypt – sequence: 8 givenname: Doaa Y. orcidid: 0000-0002-1139-7475 surname: Ali fullname: Ali, Doaa Y. organization: Department of Clinical and Chemical Pathology, Faculty of Medicine, Fayoum University, Al Fayoum, Egypt – sequence: 9 givenname: Nada F. surname: Hemeda fullname: Hemeda, Nada F. organization: Department of Genetics, Faculty of Agriculture, Fayoum University, Fayoum, Egypt – sequence: 10 givenname: Amal orcidid: 0000-0002-0150-1726 surname: Amin fullname: Amin, Amal organization: Department of Medical Microbiology and Immunology, Faculty of Medicine, Fayoum University, Al Fayoum, Egypt – sequence: 11 givenname: Marwa A. surname: Ali fullname: Ali, Marwa A. organization: Department of Biochemistry and Molecular Biology, Faculty of Medicine, Fayoum University, Al Fayoum, Egypt
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Keywords	miR-181a MTMR-3 LncRNA ANRIL miR-186 Preeclampsia
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Title	Expression profile of LncRNA ANRIL, miR-186, miR-181a, and MTMR-3 in patients with preeclampsia
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