Factors associated with protective antibody levels to vaccine preventable diseases in internationally adopted children

• Published in: Vaccine Vol. 29; no. 1; pp. 95 - 103
• Main Authors: Stadler, Laura Patricia, Donauer, Stephanie, Rice, Marilyn, Trehan, Indi, Salisbury, Shelia, Staat, Mary Allen
• Format: Journal Article
• Language: English
• Published: Kidlington Elsevier Ltd 10-12-2010; Elsevier; Elsevier Limited
• Subjects: Adolescent; Adoption; Age; Allergy and Immunology; Antibodies - blood; Applied microbiology; Biological and medical sciences; Child; Child, Preschool; Children & youth; Communicable Disease Control - methods; Communicable Diseases - immunology; Diphtheria; Disease; Documentation; Female; Fundamental and applied biological sciences. Psychology; Humans; Immunization; Infant; International adoption; Male; Measles; Microbiology; Multivariate analysis; Mumps; Serology; Studies; Tetanus; United States; Vaccination - statistics & numerical data; Vaccine preventable diseases; Vaccines; Vaccines - administration & dosage; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects); United States > US; measles mumps rubella; DTP; diphtheria tetanus pertussis; hepatitis B virus; Serology; odds ratio; SD; OPV; ACIP; UTD-V; HBV; ND-R; number-of-doses recorded; International adoption; Immunization; OR; CI; Advisory Committee on Immunization Practices; American Academy of Pediatrics; AAP; Vaccine preventable diseases; CCHMC; MMR; oral polio vaccine; 95% confidence interval; Cincinnati Children's Hospital Medical Center; enzyme-linked immunosorbent assay; up-to-date by valid doses; ELISA; standard deviation; Human; Antibody; Vaccine; Child; Adoption
• ISSN: 0264-410X; 1873-2518
• DOI: 10.1016/j.vaccine.2010.09.098

Abstract To determine which factors are predictive of protective antibody against vaccine-preventable diseases in internationally adopted children, we evaluated 562 children with serologic testing for at least one vaccine antigen before receiving a US vaccination. Vaccination status was defined as the number-of-doses recorded and as the presence of an up-to-date and valid record according to the American Academy of Pediatrics and the Advisory Committee on Immunization Practices guidelines. The number-of-doses recorded was the best predictor of protective antibody. These findings suggest that other options for immunization verification guidelines for internationally adopted children should be considered by policy makers.