Cooperation of adapter molecules in proximal signaling cascades during allergic inflammation

Activation of mast cells through their high-affinity immunoglobulin E receptor (FcεRI) plays an important role in allergic disorders. Other mast cell-activating stimuli, such as Toll-like receptor (TLR) ligands, synergize with FcεRI to enhance allergic inflammation. Thus, there is much interest in u...

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Bibliographic Details
Published in:	Immunological reviews Vol. 232; no. 1; pp. 99 - 114
Main Authors:	Kambayashi, Taku, LaRosa, David F, Silverman, Michael A, Koretzky, Gary A
Format:	Journal Article
Language:	English
Published:	Oxford, UK Oxford, UK : Blackwell Publishing Ltd 01-11-2009 Blackwell Publishing Ltd
Subjects:	adapter molecules Adaptor Proteins, Signal Transducing - immunology allergy Animals cell signaling FcεRI Humans hypersensitivity Hypersensitivity - immunology Hypersensitivity - metabolism mast cell Mast Cells - cytology Mast Cells - immunology Mast Cells - metabolism Protein Multimerization - immunology Receptor Cross-Talk Receptors, IgE - immunology Receptors, IgE - metabolism Signal Transduction - immunology TLR Toll-Like Receptors - metabolism
Online Access:	Get full text
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