Clinical and molecular pathology of aggressive schneiderian papilloma involving the temporal bone

• Published in: Head & neck Vol. 20; no. 1; pp. 83 - 88
• Main Authors: Jones, Michael E., Wackym, Phillip A., Said-Al Naief, Nasser, Brandwein, Margaret, Shaari, Christopher M., Som, Peter M., Zhang, David Y., King, Wesley A.
• Format: Journal Article
• Language: English
• Published: New York Wiley Subscription Services, Inc., A Wiley Company 01-01-1998; John Wiley & Sons
• Subjects: Adult; Base Sequence; Biological and medical sciences; Diagnosis, Differential; Female; Human papillomavirus; Humans; inverting papilloma; Medical sciences; molecular biology; Molecular Sequence Data; Non tumoral diseases; Otorhinolaryngology (head neck, general aspects and miscellaneous); Otorhinolaryngology. Stomatology; Papilloma, Inverted - diagnosis; Papilloma, Inverted - surgery; papillomavirus; Papillomavirus Infections - diagnosis; Papillomavirus Infections - pathology; Paranasal Sinus Neoplasms - diagnosis; Paranasal Sinus Neoplasms - surgery; Polymerase Chain Reaction; Skull Neoplasms - diagnosis; Skull Neoplasms - secondary; Skull Neoplasms - surgery; Temporal Bone; Tomography, X-Ray Computed; Tumor Virus Infections - diagnosis; Tumor Virus Infections - pathology; Human; Evaluation; Inverted papilloma; Temporal bone; Radiodiagnosis; Pathophysiology; Case study; Histopathology; Medical imagery; ENT disease; Clinical investigation; Computerized axial tomography; Benign neoplasm; Diagnosis; Preoperative; Molecular biology
• ISSN: 1043-3074; 1097-0347
• DOI: 10.1002/(SICI)1097-0347(199801)20:1<83::AID-HED14>3.0.CO;2-Q

Background
Inverting papilloma is a benign but locally aggressive sinonasal tumor that rarely involves the middle ear or temporal bone.
Methods
A report of a case and the molecular pathology of the tumor is presented.
Results
A 35‐year‐old woman with a history of recurrent inverting papilloma of the left paranasal sinuses was found to have evidence of extension through the eustachian tube and extensive involvement of the temporal bone. Surgical management resulted in the patient being disease‐free at 14 months. Molecular pathology studies of the resected tumor suggest an association with human papillomavirus.
Conclusions
Direct extension of the sinonasal tumor through the eustachian tube may represent the pathologic mechanism involved in the development of inverting papilloma involving the middle ear and temporal bone. © 1998 John Wiley & Sons, Inc. Head Neck 20: 83–88, 1998.