Osteosarcoma: Oncologic and functional results. A single institutional report covering 22 years

• Published in: Journal of surgical oncology Vol. 72; no. 3; pp. 124 - 129
• Main Authors: Renard, A.J.S., Veth, R.P.H., Schreuder, H.W.B., Pruszczynski, M., Bökkerink, J.P.M., van Hoesel, Q.G.C.M., van der Staak, F.J.M.
• Format: Journal Article
• Language: English
• Published: New York John Wiley & Sons, Inc 01-11-1999; Wiley-Liss
• Subjects: Adolescent; Adult; Aged; Biological and medical sciences; Bone Neoplasms - mortality; Bone Neoplasms - physiopathology; Bone Neoplasms - therapy; chemotherapy; Child; Child, Preschool; Disease-Free Survival; Diseases of the osteoarticular system; Female; functional results; Humans; Male; Medical sciences; Middle Aged; Neoplasm Recurrence, Local; osteosarcoma; Osteosarcoma - mortality; Osteosarcoma - physiopathology; Osteosarcoma - therapy; surgery; survival; Tumors of striated muscle and skeleton; Human; Indication; Treatment efficiency; Mortality; Lung; Diseases of the osteoarticular system; Adjuvant treatment; Malignant tumor; Metastasis; Conservative surgery; Osteosarcoma; Surgery; Bone; Survival curve
• ISSN: 0022-4790; 1096-9098
• DOI: 10.1002/(SICI)1096-9098(199911)72:3<124::AID-JSO3>3.0.CO;2-G

Background and Objectives
The oncologic and functional results in patients treated because of osteosarcoma (OS) were evaluated.
Methods
Fifty‐one patients with high‐grade OS were treated between 1974 and 1996 at our hospital. All patient records were studied, and the surviving patients were evaluated according to the American Musculoskeletal Tumor Society functional rating system. The majority of patients received adjuvant chemotherapy (prior to 1983) or neoadjuvant chemotherapy (from 1983). Until 1987, all patients with extremity OS had ablative surgery; from 1987, the majority had limb‐saving surgery. Lung metastases were resected in most cases.
Results
Overall 2‐year and 5‐year disease‐free survival (DFS) rates were 27 of 51 and 16 of 42, respectively. Patients with vertebral or pelvic OS or contaminated margins after resection had a very bad outcome. In all other subgroups, including patients with various types of chemotherapy, response to chemotherapy, diameter of tumor, presence or absence of metastatic spread, and location of tumor, a 5‐year DFS of about 50% was found. Recurrent disease in patients who had achieved a 2‐year disease‐free interval was relatively low (4/23 patients).
Conclusions
Survival in our series was worse than in most other studies. A very bad outcome was found in patients with vertebral or pelvic OS or with contaminated margins after resection. J. Surg. Oncol. 1999;72:124–129. © 1999 Wiley‐Liss, Inc.