IL‐6 572 C/G, 190 C/T, and 174 G/C Gene Polymorphisms in Children's Malnutrition

• Published in: Journal of pediatric gastroenterology and nutrition Vol. 59; no. 5; pp. 666 - 673
• Main Authors: Marginean, Cristina O., Banescu, Claudia, Voidazan, Septimiu, Duicu, Carmen
• Format: Journal Article
• Language: English
• Published: United States by European Society for Pediatric Gastroenterology, Hepatology, and Nutrition and North American Society for Pediatric Gastroenterology 01-11-2014
• Subjects: Adolescent; Alleles; Arm; Body Mass Index; Child; Child Nutrition Disorders - genetics; Child, Preschool; children; Female; Genotype; Heterozygote; Hospitalization; Humans; IL‐6 gene 174 G/C polymorphism; IL‐6 gene 190 C/T polymorphism; IL‐6 gene 572 C/G polymorphism; Infant; Interleukin-6 - genetics; Male; malnutrition; Malnutrition - genetics; Nutritional Status - genetics; Polymorphism, Single Nucleotide; Serum Albumin - genetics
• ISSN: 0277-2116; 1536-4801
• DOI: 10.1097/MPG.0000000000000492

ABSTRACT
Objectives:
The aim of the present study was to establish the correlations between the polymorphisms of the genes interleukin‐6 (IL‐6) 572, 190, and 174 in children's malnutrition.
Methods:
We assessed 283 hospitalized children and divided them into 2 groups: group I (control) included 110 patients with normal nutritional status, median (range) age 10.90 (1–18) years; and group II consisted of 173 malnourished patients, median (range) age 10.70 (1–18) years.
Results:
The 2 groups underwent IL‐6 572 cytosine allele (C)/guanine allele (G), 190 C/thymine allele (T), and 174 G/C polymorphism testing, measurement of anthropometric indicators (mid‐upper arm circumference and tricipital skinfold thickness [TST]), and paraclinical evaluation (protein, albumin). We observed that the GG and CG genotypes were more frequent in malnourished children for the IL‐6 174 gene (P = 0.0001), whereas the CT heterozygous genotype was more frequent in the malnourished group for the IL‐6 190 gene (P = 0.003). Body mass index (BMI), middle upper arm circumference (MUAC), TST, and low serum albumin levels correlated with the GG and CG genotypes of the IL‐6 572 and IL‐6 174 genes, and with the CT genotype of the IL‐6 190 gene, in children with malnutrition, whereas the IL‐6 190 TT genotype was a protective factor for malnutrition (P = 0.0001).
Conclusions:
Malnutrition is more frequently associated in children with IL‐6 174 G allele carriers (GG and CG genotypes), whereas IL‐6 190 TT genotype has a protective function. In malnourished children, the IL‐6 572/190/174 GG/CT/CG, GG/CT/GG, GG/CC/GG, and GG/CC/CG combined genotypes are more frequent.