LAG-3 Inhibitory Receptor Expression Identifies Immunosuppressive Natural Regulatory Plasma Cells

B lymphocytes can suppress immunity through interleukin (IL)-10 production in infectious, autoimmune, and malignant diseases. Here, we have identified a natural plasma cell subset that distinctively expresses the inhibitory receptor LAG-3 and mediates this function in vivo. These plasma cells also e...

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Published in:	Immunity (Cambridge, Mass.) Vol. 49; no. 1; pp. 120 - 133.e9
Main Authors:	Lino, Andreia C., Dang, Van Duc, Lampropoulou, Vicky, Welle, Anna, Joedicke, Jara, Pohar, Jelka, Simon, Quentin, Thalmensi, Jessie, Baures, Aurelia, Flühler, Vinciane, Sakwa, Imme, Stervbo, Ulrik, Ries, Stefanie, Jouneau, Luc, Boudinot, Pierre, Tsubata, Takeshi, Adachi, Takahiro, Hutloff, Andreas, Dörner, Thomas, Zimber-Strobl, Ursula, de Vos, Alex F., Dahlke, Katja, Loh, Gunnar, Korniotis, Sarantis, Goosmann, Christian, Weill, Jean-Claude, Reynaud, Claude-Agnès, Kaufmann, Stefan H.E., Walter, Jörn, Fillatreau, Simon
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 17-07-2018 Elsevier Limited Elsevier Cell Press
Subjects:	Animals Antigens, CD - genetics Antigens, CD - immunology B cells B-cell receptor B-Lymphocyte Subsets - immunology BCR Binding sites CD200 antigen CD223 antigen CD72 checkpoint receptor Deoxyribonucleic acid DNA DNA methylation Epigenesis, Genetic Female Gene Expression Gene Expression Profiling Genes Genomes immune regulation Immunity Immunoglobulins Immunological memory Immunosuppression Immunosuppressive agents infection Infections Interleukin 1 Interleukin 10 Interleukin-10 - biosynthesis Interleukin-10 - genetics LAG-3 Life Sciences Lymphocyte Activation Lymphocytes Lymphocytes B Lymphocytes T Male Mice Microbiota Morphology natural regulatory plasma cell PD-L1 protein Plasma cells Plasma Cells - immunology Plasma Cells - physiology Receptor mechanisms Receptors Receptors, Antigen, B-Cell - metabolism Regulation Salmonella Salmonella Infections, Animal - immunology Signal Transduction T-Lymphocytes - immunology TLR Toll-like receptors Toll-Like Receptors - metabolism Up-Regulation - genetics Vaccine efficacy Vaccines - immunology United States > US BCR infection CD72 LAG-3 natural regulatory plasma cell B cells TLR plasma cells checkpoint receptor interleukin-10 immune regulation generation il-10 transcription factor differentiation autoimmunity protective immunity i CD4(+) T-CELLS b-cells gene-expression n-vivo
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