Eco1-Dependent Cohesin Acetylation During Establishment of Sister Chromatid Cohesion
Replicated chromosomes are held together by the chromosomal cohesin complex from the time of their synthesis in S phase onward. This requires the replication fork-associated acetyl transferase Eco1, but Eco1's mechanism of action is not known. We identified spontaneous suppressors of the thermo...
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| Published in: | Science (American Association for the Advancement of Science) Vol. 321; no. 5888; pp. 563 - 566 |
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| Main Authors: | , , , , , , |
| Format: | Journal Article |
| Language: | English |
| Published: |
Washington, DC
American Association for the Advancement of Science
25-07-2008
The American Association for the Advancement of Science |
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| Abstract | Replicated chromosomes are held together by the chromosomal cohesin complex from the time of their synthesis in S phase onward. This requires the replication fork-associated acetyl transferase Eco1, but Eco1's mechanism of action is not known. We identified spontaneous suppressors of the thermosensitive eco1-1 allele in budding yeast. An acetylation-mimicking mutation of a conserved lysine in cohesin's Smc3 subunit makes Eco1 dispensable for cell growth, and we show that Smc3 is acetylated in an Eco1-dependent manner during DNA replication to promote sister chromatid cohesion. A second set of eco1-1 suppressors inactivate the budding yeast ortholog of the cohesin destabilizer Wapl. Our results indicate that Eco1 modifies cohesin to stabilize sister chromatid cohesion in parallel with a cohesion establishment reaction that is in principle Eco1-independent. |
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| AbstractList | Replicated chromosomes are held together by the chromosomal cohesin complex from the time of their synthesis in S phase onward. This requires the replication fork-associated acetyl transferase Eco1, but Eco1's mechanism of action is not known. We identified spontaneous suppressors of the thermosensitive eco1-1 allele in budding yeast. An acetylation-mimicking mutation of a conserved lysine in cohesin's Smc3 subunit makes Eco1 dispensable for cell growth, and we show that Smc3 is acetylated in an Eco1-dependent manner during DNA replication to promote sister chromatid cohesion. A second set of eco1-1 suppressors inactivate the budding yeast ortholog of the cohesin destabilizer Wapl. Our results indicate that Eco1 modifies cohesin to stabilize sister chromatid cohesion in parallel with a cohesion establishment reaction that is in principle Eco1-independent. Replicated chromosomes are held together by the chromosomal cohesin complex from the time of their synthesis in S phase onward. This requires the replication fork-associated acetyl transferase Eco1, but Eco1's mechanism of action is not known. We identified spontaneous suppressors of the thermosensitive eco1-1 allele in budding yeast. An acetylation-mimicking mutation of a conserved lysine in cohesin's Smc3 subunit makes Eco1 dispensable for cell growth, and we show that Smc3 is acetylated in an Eco1-dependent manner during DNA replication to promote sister chromatid cohesion. A second set of eco1-1 suppressors inactivate the budding yeast ortholog of the cohesin destabilizer Wapl. Our results indicate that Eco1 modifies cohesin to stabilize sister chromatid cohesion in parallel with a cohesion establishment reaction that is in principle Eco1-independent. [PUBLICATION ABSTRACT] |
| Author | Heeger, Sebastian East, Philip Flynn, Helen Skehel, Mark Ben-Shahar, Tom Rolef Uhlmann, Frank Lehane, Chris |
| Author_xml | – sequence: 1 fullname: Ben-Shahar, Tom Rolef – sequence: 2 fullname: Heeger, Sebastian – sequence: 3 fullname: Lehane, Chris – sequence: 4 fullname: East, Philip – sequence: 5 fullname: Flynn, Helen – sequence: 6 fullname: Skehel, Mark – sequence: 7 fullname: Uhlmann, Frank |
| BackLink | http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=20551943$$DView record in Pascal Francis https://www.ncbi.nlm.nih.gov/pubmed/18653893$$D View this record in MEDLINE/PubMed |
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| SubjectTerms | Acetylation Acetyltransferases - chemistry Acetyltransferases - genetics Acetyltransferases - metabolism Alleles Biochemistry Biological and medical sciences Biomedical research Cell cycle Cell Cycle Proteins - chemistry Cell Cycle Proteins - genetics Cell Cycle Proteins - metabolism Chemical synthesis Chondroitin Sulfate Proteoglycans - chemistry Chondroitin Sulfate Proteoglycans - genetics Chondroitin Sulfate Proteoglycans - metabolism Chromatids Chromatids - physiology Chromosomal Proteins, Non-Histone - chemistry Chromosomal Proteins, Non-Histone - genetics Chromosomal Proteins, Non-Histone - metabolism Chromosomes Chromosomes, Fungal - physiology Complementation Diploidy DNA Repair DNA Replication DNA, Fungal - metabolism Fundamental and applied biological sciences. Psychology Genetic mutation Genetics Interphase Molecular and cellular biology Molecular genetics Mutation Nuclear Proteins - chemistry Nuclear Proteins - genetics Nuclear Proteins - metabolism Protein Subunits - chemistry Protein Subunits - genetics Protein Subunits - metabolism Replication S Phase Saccharomyces cerevisiae Saccharomyces cerevisiae - genetics Saccharomyces cerevisiae - growth & development Saccharomyces cerevisiae - physiology Saccharomyces cerevisiae Proteins - chemistry Saccharomyces cerevisiae Proteins - genetics Saccharomyces cerevisiae Proteins - metabolism Saccharomycetales Suppression, Genetic |
| Title | Eco1-Dependent Cohesin Acetylation During Establishment of Sister Chromatid Cohesion |
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