Expanding the genetic toolkit in Xenopus: Approaches and opportunities for human disease modeling

The amphibian model Xenopus, has been used extensively over the past century to study multiple aspects of cell and developmental biology. Xenopus offers advantages of a non-mammalian system, including high fecundity, external development, and simple housing requirements, with additional advantages o...

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Bibliographic Details
Published in:	Developmental biology Vol. 426; no. 2; pp. 325 - 335
Main Authors:	Tandon, Panna, Conlon, Frank, Furlow, J. David, Horb, Marko E.
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 15-06-2017
Subjects:	Animal Husbandry - organization & administration Animals Base Pairing CRISPR-Cas CRISPR-Cas Systems Disease Models, Animal Gene Editing - methods Gene Knock-In Techniques Gene Knockout Techniques Genome Human disease model Humans J strain Knock-in Laboratory Animal Science - organization & administration Selective Breeding TALENs Tetraploidy Transcription Activator-Like Effector Nucleases Xenopus - genetics Xenopus laevis Xenopus laevis - genetics Xenopus tropicalis TALENs Xenopus laevis CRISPR-Cas J strain Xenopus tropicalis Knock-in Human disease model
Online Access:	Get full text
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