Recent Developments on the Roles of Calcium Signals and Potential Therapy Targets in Cervical Cancer

• Published in: Cells (Basel, Switzerland) Vol. 11; no. 19; p. 3003
• Main Authors: Lei, Jiahui, Deng, Fengying, Ding, Hongmei, Fu, Mengyu, Xu, Ting, Ji, Bingyu, Feng, Lin, Li, Min, Qiu, Junlan, Gao, Qinqin
• Format: Journal Article
• Language: English
• Published: Basel MDPI AG 26-09-2022; MDPI
• Subjects: Acids; Antitumor activity; Apoptosis; Breast cancer; Ca2+ signals; Calcium (intracellular); Calcium signalling; Calcium, Dietary; Cancer therapies; Cell cycle; Cell growth; Cervical cancer; Cervix; development; Drug development; Drug targeting; Drug therapy; Gene expression; Homeostasis; Human papillomavirus; Ligands; Medical prognosis; Metastases; Metastasis; Methods; Mortality; occurrence; Physiological aspects; prognosis; Prostate cancer; Proteins; Review; Signal transduction; Therapeutic targets; China
• ISSN: 2073-4409; 2073-4409
• DOI: 10.3390/cells11193003

Intracellular calcium (Ca2+) concentration ([Ca2+]i) is implicated in proliferation, invasion, and metastasis in cancerous tissues. A variety of oncologic therapies and some candidate drugs induce their antitumor effects (in part or in whole) through the modulation of [Ca2+]i. Cervical cancer is one of most common cancers among women worldwide. Recently, major research advances relating to the Ca2+ signals in cervical cancer are emerging. In this review, we comprehensively describe the current progress concerning the roles of Ca2+ signals in the occurrence, development, and prognosis of cervical cancer. It will enhance our understanding of the causative mechanism of Ca2+ signals in cervical cancer and thus provide new sights for identifying potential therapeutic targets for drug discovery.