Melanoma: BRAFi Rechallenge
Melanoma is the most aggressive type of skin cancer. Half of melanoma cases are characterized by the mutation BRAF V600. The case presented concerns a 41-year-old patient with locally advanced melanoma, being positive in mutation BRAF V600. The patient underwent surgery and received additional targe...
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| Published in: | Medicina (Kaunas, Lithuania) Vol. 59; no. 5; p. 975 |
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| Abstract | Melanoma is the most aggressive type of skin cancer. Half of melanoma cases are characterized by the mutation BRAF V600. The case presented concerns a 41-year-old patient with locally advanced melanoma, being positive in mutation BRAF V600. The patient underwent surgery and received additional targeted therapy as part of a clinical study. In subsequent disease progression, immunotherapy was used. When the disease progressed again while the patient was in a good performance status, targeted therapy was administered again, and a good response was noted, making the patient reach a statistically significant overall survival, exceeding four years. Targeted therapy has proven to be an important tool in the treatment of melanoma. The use of BRAFi targeted therapy does not exclude the option of readministration at subsequent disease progression (BRAFi rechallenge). Preclinical models suggest that the resistance mechanism of cancer cells to BRAFi therapy bends, as these cell clones lose their evolutionary advantage after stopping BRAFi. Cell clones sensitive to BRAFi may then outcompete, making the treatment effective again. Therapeutical dilemmas in the management of patients with locally advanced melanoma that progresses to metastatic cancer are discussed. |
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| AbstractList | Melanoma is the most aggressive type of skin cancer. Half of melanoma cases are characterized by the mutation BRAF V600. The case presented concerns a 41-year-old patient with locally advanced melanoma, being positive in mutation BRAF V600. The patient underwent surgery and received additional targeted therapy as part of a clinical study. In subsequent disease progression, immunotherapy was used. When the disease progressed again while the patient was in a good performance status, targeted therapy was administered again, and a good response was noted, making the patient reach a statistically significant overall survival, exceeding four years. Targeted therapy has proven to be an important tool in the treatment of melanoma. The use of BRAFi targeted therapy does not exclude the option of readministration at subsequent disease progression (BRAFi rechallenge). Preclinical models suggest that the resistance mechanism of cancer cells to BRAFi therapy bends, as these cell clones lose their evolutionary advantage after stopping BRAFi. Cell clones sensitive to BRAFi may then outcompete, making the treatment effective again. Therapeutical dilemmas in the management of patients with locally advanced melanoma that progresses to metastatic cancer are discussed. |
| Audience | Academic |
| Author | Papadopoulos, Konstantinos Varsamis, Nikolaos Theodorou, Vasiliki Papadopoulou, Eleni Georgakoudi, Eleni Koulouris, Charilaos Kosmidis, Christoforos S Papadopoulou, Evanthia Baka, Sofia Papadopoulou, Konstantina Miltiadous, Petrina Sevva, Christina Mantalovas, Stylianos Petanidis, Savvas Mystakidou, Chrysi Maria |
| AuthorAffiliation | 2 3rd Surgical Department, “AHEPA” University Hospital of Thessaloniki, School of Medicine, Aristotle University of Thessaloniki, 1st St. Kiriakidi Street, 54621 Thessaloniki, Greece 3 1st Department of Internal Medicine, G. Papanikolaou General Hospital of Thessaloniki, 57010 Thessaloniki, Greece 6 Laboratory of Medical Biology and Genetics, Department of Medicine, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece 4 Medical School, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece 5 Shakolas Educational Centre for Clinical Medicine, University of Cyprus, Old Road Nicosia-Lemesos 215/6, 2029 Nicosia, Cyprus 1 European Interbalkan Medical Center, 10 Asklipiou Street, 55535 Pylaia, Greece; dr.ckosmidis@gmail.com (C.S.K.) |
| AuthorAffiliation_xml | – name: 3 1st Department of Internal Medicine, G. Papanikolaou General Hospital of Thessaloniki, 57010 Thessaloniki, Greece – name: 5 Shakolas Educational Centre for Clinical Medicine, University of Cyprus, Old Road Nicosia-Lemesos 215/6, 2029 Nicosia, Cyprus – name: 6 Laboratory of Medical Biology and Genetics, Department of Medicine, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece – name: 1 European Interbalkan Medical Center, 10 Asklipiou Street, 55535 Pylaia, Greece; dr.ckosmidis@gmail.com (C.S.K.) – name: 4 Medical School, Faculty of Health Sciences, Aristotle University of Thessaloniki, 54124 Thessaloniki, Greece – name: 2 3rd Surgical Department, “AHEPA” University Hospital of Thessaloniki, School of Medicine, Aristotle University of Thessaloniki, 1st St. Kiriakidi Street, 54621 Thessaloniki, Greece |
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| Cites_doi | 10.18632/oncotarget.26149 10.1016/j.ejca.2017.12.007 10.1007/s11864-022-01006-7 10.3390/cancers12102801 10.1073/pnas.2113535119 10.1038/nature11814 10.2174/1871520620666200422073622 10.1016/S1470-2045(17)30171-7 10.3390/ijms21249730 10.1111/jdv.14268 10.1038/s41573-019-0044-1 10.1016/j.bbagen.2020.129736 10.1056/NEJMoa2005493 10.1097/CMR.0000000000000821 |
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| Keywords | targeted therapy BRAF inhibitor BRAFi rechallenge metastatic melanoma BRAF V600 mutation |
| Language | English |
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| References | Salangsang (ref_5) 2013; 494 Kavran (ref_12) 2022; 119 Manzano (ref_4) 2022; 23 ref_14 Dummer (ref_1) 2020; 383 Amann (ref_8) 2017; 31 Awada (ref_13) 2022; 32 Tangella (ref_10) 2021; 1865 Valpione (ref_3) 2018; 91 Li (ref_6) 2020; 20 Boumahdi (ref_11) 2020; 19 ref_9 Tietze (ref_2) 2018; 9 Schreuer (ref_7) 2017; 18 |
| References_xml | – volume: 9 start-page: 34336 year: 2018 ident: ref_2 article-title: The efficacy of re-challenge with BRAF inhibitors after previous progression to BRAF inhibitors in melanoma: A retrospective multicenter study publication-title: Oncotarget doi: 10.18632/oncotarget.26149 contributor: fullname: Tietze – volume: 91 start-page: 116 year: 2018 ident: ref_3 article-title: Rechallenge with BRAF-directed treatment in metastatic melanoma: A multi-institutional retrospective study publication-title: Eur. J. Cancer doi: 10.1016/j.ejca.2017.12.007 contributor: fullname: Valpione – volume: 23 start-page: 1503 year: 2022 ident: ref_4 article-title: BRAF Inhibitor Resistance in Melanoma: Mechanisms and Alternative Therapeutic Strategies publication-title: Curr. Treat. Options Oncol. doi: 10.1007/s11864-022-01006-7 contributor: fullname: Manzano – ident: ref_9 doi: 10.3390/cancers12102801 – volume: 119 start-page: e2113535119 year: 2022 ident: ref_12 article-title: Intermittent treatment of BRAF melanoma cells delays resistance by adaptive resensitization to drug rechallenge publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.2113535119 contributor: fullname: Kavran – volume: 494 start-page: 251 year: 2013 ident: ref_5 article-title: Modelling vemurafenib resistance in melanoma reveals a strategy to forestall drug resistance publication-title: Nature doi: 10.1038/nature11814 contributor: fullname: Salangsang – volume: 20 start-page: 1415 year: 2020 ident: ref_6 article-title: Promising Strategies for Overcoming BRAF Inhibitor Resistance Based on Known Resistance Mechanisms publication-title: Anticancer Agents Med. Chem. doi: 10.2174/1871520620666200422073622 contributor: fullname: Li – volume: 18 start-page: 464 year: 2017 ident: ref_7 article-title: Combination of dabrafenib plus trametinib for BRAF and MEK inhibitor pretreated patients with advanced BRAF publication-title: Lancet Oncol. doi: 10.1016/S1470-2045(17)30171-7 contributor: fullname: Schreuer – ident: ref_14 doi: 10.3390/ijms21249730 – volume: 31 start-page: 1638 year: 2017 ident: ref_8 article-title: Successful retreatment with combined BRAF/MEK inhibition in metastatic BRAFV600-mutated melanoma publication-title: J. Eur. Acad. Dermatol. Venereol. doi: 10.1111/jdv.14268 contributor: fullname: Amann – volume: 19 start-page: 39 year: 2020 ident: ref_11 article-title: The great escape: Tumour cell plasticity in resistance to targeted therapy publication-title: Nat. Rev. Drug. Discov. doi: 10.1038/s41573-019-0044-1 contributor: fullname: Boumahdi – volume: 1865 start-page: 129736 year: 2021 ident: ref_10 article-title: Resistance mechanisms to targeted therapy in BRAF-mutant melanoma—A mini review publication-title: Biochim. Biophys. Acta Gen. Subj. doi: 10.1016/j.bbagen.2020.129736 contributor: fullname: Tangella – volume: 383 start-page: 1139 year: 2020 ident: ref_1 article-title: Five-Year Analysis of Adjuvant Dabrafenib plus Trametinib in Stage III Melanoma publication-title: N. Engl. J. Med. doi: 10.1056/NEJMoa2005493 contributor: fullname: Dummer – volume: 32 start-page: 183 year: 2022 ident: ref_13 article-title: A lead-in safety study followed by a phase 2 clinical trial of dabrafenib, trametinib and hydroxychloroquine in advanced BRAFV600 mutant melanoma patients previously treated with BRAF-/MEK-inhibitors and immune checkpoint inhibitors publication-title: Melanoma Res. doi: 10.1097/CMR.0000000000000821 contributor: fullname: Awada |
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| SubjectTerms | Adult Antimitotic agents Antineoplastic agents Biopsy BRAF inhibitor BRAF V600 mutation BRAFi rechallenge Care and treatment Case Report Clinical trials Development and progression Disease Progression Health aspects Humans Immunotherapy Lymphatic system Medical imaging Medical prognosis Medical research Medicine, Experimental Melanoma Melanoma - genetics Metastasis metastatic melanoma Mutation Patients Protein Kinase Inhibitors - therapeutic use Proto-Oncogene Proteins B-raf - genetics Skin cancer Skin Neoplasms - pathology Steroids targeted therapy |
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| Title | Melanoma: BRAFi Rechallenge |
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