Higher Frequency of the ACTN3 R Allele + ACE DD Genotype in Japanese Elite Wrestlers

• Published in: Journal of strength and conditioning research Vol. 26; no. 12; pp. 3275 - 3280
• Main Authors: Kikuchi, Naoki, Min, Seok-ki, Ueda, Dai, Igawa, Shoji, Nakazato, Koichi
• Format: Journal Article
• Language: English
• Published: United States National Strength and Conditioning Association 01-12-2012; Lippincott Williams & Wilkins Ovid Technologies
• Subjects: ACE inhibitors; ACE protein; Actinin - genetics; Adult; Alleles; Asian Continental Ancestry Group - genetics; Case-Control Studies; Chi-Square Distribution; College health; College students; Comparative analysis; Data processing; Enzymes; Gene frequency; Gene polymorphism; Genetics; Genotype; Genotype & phenotype; Humans; Logistic Models; Male; Olympics; Peptidyl-dipeptidase A; Peptidyl-Dipeptidase A - genetics; Physical education; Polymorphism; Polymorphism, Genetic; Strength (performance); Tournaments; Wrestling; Japan
• ISSN: 1064-8011; 1533-4287
• DOI: 10.1519/JSC.0b013e318273679d

ABSTRACTKikuchi, N, Min, S-K, Ueda, D, Igawa, S, and Nakazato, K. Higher frequency of the ACTN3 R allele + ACE DD genotype in Japanese elite wrestlers. J Strength Cond Res 26(12)3275–3280, 2012—In this study, the authors investigated the association between the ACTN3 and angiotensin-converting enzyme (ACE) genotypes and the performance of 135 Japanese elite male wrestlers. Fifty-two wrestlers had participated in world championships, including the Olympic Games, or had placed first in Japanese national championships and were classified as “international.” The remaining 83 wrestlers were classified as “national.” The control group consisted of 333 healthy Japanese college students majoring in physical education. In the ACTN3 genotype distribution, a significant difference between the international and control groups was observed (p < 0.05). The ACE genotype distribution and allele frequency of all wrestlers significantly differed from those of the control subjects (p < 0.001). As compared with the control group, the odds ratio of the ACTN3 R allele + ACE DD genotype being international or national was 3.85 (95% confidence interval [CI], 2.10–7.03) or 1.37 (95% CI, 0.79–2.36), respectively. Our data suggest that the combination of ACTN3 and ACE gene polymorphisms is associated with the athletic status of Japanese elite wrestlers.