EGFR rs11506105 and IFNL3 SNPs but not rs8099917 are strongly associated with treatment responses in Iranian patients with chronic hepatitis C

• Published in: Genes and immunity Vol. 18; no. 3; pp. 144 - 151
• Main Authors: Asnavandi, M, Zargar, M, Vaziri, F, Jamnani, F R, Gharibzadeh, S, Fateh, A, Siadat, S D
• Format: Journal Article
• Language: English
• Published: London Nature Publishing Group UK 01-09-2017; Nature Publishing Group
• Subjects: 45/22; 45/23; 45/77; 631/250/254; 631/250/255/234/2513/1551; Adult; Biomedical and Life Sciences; Biomedicine; Cancer Research; Case-Control Studies; Development and progression; Epidermal growth factor; Epidermal growth factor receptors; ErbB Receptors - genetics; Female; Gene Expression; Gene polymorphism; Genetic aspects; Hepatitis; Hepatitis C; Hepatitis C, Chronic - drug therapy; Hepatitis C, Chronic - genetics; Human Genetics; Humans; Immunology; Interferon; Interferons; Interleukins - genetics; Iran; Male; Middle Aged; original-article; Patients; Physiological aspects; Polymorphism; Polymorphism, Single Nucleotide; Restriction fragment length polymorphism; Single nucleotide polymorphisms; Single-nucleotide polymorphism; Sustained Virologic Response; Iran
• ISSN: 1466-4879; 1476-5470
• DOI: 10.1038/gene.2017.12

Interferon lambda 3 (
IFNL3
) and epidermal growth factor receptor (
EGFR
) single nucleotide polymorphisms (SNPs) may play a key role in the spontaneous clearance of hepatitis C virus (HCV) and treatment responses. The aim of this study was to evaluate the effect of
IFNL3
SNPs and
EGFR
rs11506105 on treatment outcomes in patients with chronic HCV (CHC).
IFNL3
SNPs and
EGFR
rs11506105 were genotyped by PCR-restriction fragment length polymorphism and PCR-sequencing, respectively, in 235 naïve patients with CHC infection. The frequency of rapid virologic response (RVR), complete early virologic response (cEVR) and sustained virologic response (SVR) were 52.3%, 76.2% and 64.7% respectively. The results of this study showed that RVR was associated with ALT (
P
=0.015), AST (
P
=0.020),
IFNL3
rs12979860 (CC) (
P
=0.043), rs12980275 (AA) (
P
=1 × 10
−4
), and
EGFR
rs11506105 (AA) (
P
=0.010), and
IFNL3
rs12979860 (CC) (
P
=0.048), rs12980275 (AA) (
P
=0.022), and
EGFR
rs11506105 (AA) (
P
=0.006) were correlated with cEVR. HCV genotype (
P
=0.007),
IFNL3
rs12979860 (CC) (
P
=0.023),
IFNL3
rs12980275 (AA) (
P
=1 × 10
−4
),
EGFR
rs11506105 (AA) (
P
=0.005), RVR (
P
=1 × 10
−4
), and cEVR (
P
=0.003) were significant predictors for SVR. These results, for the first time, revealed that beside
IFNL3
SNPs,
EGFR
rs11506105 is strongly associated with RVR, cEVR and SVR.
EGFR
rs11506105 besides
IFNL3
SNPs could predict treatment responses in CHC patients.